{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["133(3)"],"submitter":["Gregory ER"],"pubmed_abstract":["<h4>Aims</h4>The purpose of this study was to compare the effect of hop extracts with diverse β-acid concentrations on Streptococcus mutans biofilm formation.<h4>Methods and results</h4>Ten different hop extracts, with α-acid concentrations similar to those found in commercial beer products and β-acid concentrations ranging from 2.6 to 8.1%, were added to distilled water to make standardized concentrations. S. mutans isolates were treated with hop extract dilutions varying from 1:2 to 1:256. The minimum inhibitory, minimum bactericidal and minimum biofilm inhibitory concentrations were determined and the optical density was evaluated. Live/dead staining confirmed the bactericidal effects. Biofilm formation of several strains of S. mutans was significantly inhibited by hop extract dilutions of 1:2, 1:4, 1:8, 1:16 and 1:32. Strong negative correlations were observed between α- and β-acid concentrations of the hop extracts and S. mutans total growth and biofilm formation.<h4>Conclusions</h4>The use of hop extracts prepared similarly to commercial beer decreased S. mutans biofilm formation.<h4>Significance and impact of the study</h4>The inclusion of hops in the commercial beer products may provide beneficial health effects. Further studies are warranted to determine an effect in vivo on the development of dental caries."],"journal":["Journal of applied microbiology"],"pagination":["1333-1340"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543398"],"repository":["biostudies-literature"],"pubmed_title":["Evaluating hop extract concentrations found in commercial beer to inhibit Streptococcus mutans biofilm formation."],"pmcid":["PMC9543398"],"pubmed_authors":["Moser EAS","Gregory RL","Bakhaider RF","Gomez GF","Gregory ER","Huang R"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating hop extract concentrations found in commercial beer to inhibit Streptococcus mutans biofilm formation.","description":"<h4>Aims</h4>The purpose of this study was to compare the effect of hop extracts with diverse β-acid concentrations on Streptococcus mutans biofilm formation.<h4>Methods and results</h4>Ten different hop extracts, with α-acid concentrations similar to those found in commercial beer products and β-acid concentrations ranging from 2.6 to 8.1%, were added to distilled water to make standardized concentrations. S. mutans isolates were treated with hop extract dilutions varying from 1:2 to 1:256. The minimum inhibitory, minimum bactericidal and minimum biofilm inhibitory concentrations were determined and the optical density was evaluated. Live/dead staining confirmed the bactericidal effects. Biofilm formation of several strains of S. mutans was significantly inhibited by hop extract dilutions of 1:2, 1:4, 1:8, 1:16 and 1:32. Strong negative correlations were observed between α- and β-acid concentrations of the hop extracts and S. mutans total growth and biofilm formation.<h4>Conclusions</h4>The use of hop extracts prepared similarly to commercial beer decreased S. mutans biofilm formation.<h4>Significance and impact of the study</h4>The inclusion of hops in the commercial beer products may provide beneficial health effects. Further studies are warranted to determine an effect in vivo on the development of dental caries.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T20:03:49.641Z","creation":"2025-04-04T20:03:49.641Z"},"accession":"S-EPMC9543398","cross_references":{"pubmed":["35598180"],"doi":["10.1111/jam.15632"]}}