biostudies-literatureSpath CQueen Silvia Foundation Anniversary FundVetenskapsrådetVästerbotten County Council/Region VästerbottenSwedish Nutrition Foundation1701-1708https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543447biostudies-literatureUnknown111(9)<h4>Aim</h4>The aim of this study was to investigate the associations between sodium supply, fluid volume, sodium imbalances and severe intraventricular haemorrhage (IVH) in extremely preterm (EPT) infants.<h4>Methods</h4>We used data from the EXtremely PREterm infants in Sweden Study (EXPRESS) cohort consisting of all infants born at 22 to 26 gestational weeks from 2004 to 2007 and conducted a nested case-control study. For every infant with severe IVH (grade 3 or peri-ventricular haemorrhagic infarction), one IVH-free control infant with the birthday closest to the case infant and matched for hospital, sex, gestational age and birth weight was selected (n = 70 case-control pairs).<h4>Results</h4>Total sodium supply and fluid volume were higher in infants with severe IVH compared with conActa paediatrica (Oslo, Norway : 1992)Sodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants.PMC95434472017-102016‐020952016-02095Agren JDomellof MStoltz Sjostrom ESpath CAhlsson FfalseSodium supply from administered blood products was associated with severe intraventricular haemorrhage in extremely preterm infants.<h4>Aim</h4>The aim of this study was to investigate the associations between sodium supply, fluid volume, sodium imbalances and severe intraventricular haemorrhage (IVH) in extremely preterm (EPT) infants.<h4>Methods</h4>We used data from the EXtremely PREterm infants in Sweden Study (EXPRESS) cohort consisting of all infants born at 22 to 26 gestational weeks from 2004 to 2007 and conducted a nested case-control study. For every infant with severe IVH (grade 3 or peri-ventricular haemorrhagic infarction), one IVH-free control infant with the birthday closest to the case infant and matched for hospital, sex, gestational age and birth weight was selected (n = 70 case-control pairs).<h4>Results</h4>Total sodium supply and fluid volume were higher in infants with severe IVH compared with con2022-01-01T00:00:00Z2022 Sep2025-04-22T12:07:57.771Z2025-04-06T00:12:51.126ZS-EPMC95434473561586810.1111/apa.16423