{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(34)"],"submitter":["Wu Y"],"pubmed_abstract":["Multifunctional porphyrin-peptide conjugates with different propensities for self-assembly into various supramolecular nanoarchitectures play important roles in advanced materials and biomedical research. However, preparing prefunctionalized core porphyrins by traditional low-yielding statistical synthesis and purifying them after peptide ligation through many rounds of HPLC purification is tedious and unsustainable. Herein, we report a novel integrated solid-phase synthetic protocol for the construction of porphyrin moieties from simple aldehydes and dipyrromethanes on resin-bound peptides directly to form mono-, cis/trans-di-, and trivalent porphyrin-peptide conjugates in a highly efficient and controllable manner; moreover, only single final-stage HPLC purification of the products is ne"],"journal":["Angewandte Chemie (International ed. in English)"],"pagination":["e202207532"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543522"],"repository":["biostudies-literature"],"pubmed_title":["Versatile Synthesis of Multivalent Porphyrin-Peptide Conjugates by Direct Porphyrin Construction on Resin."],"pmcid":["PMC9543522"],"pubmed_authors":["Chan WL","Chau HF","Wong KL","Thor W","Kai HY","Wu Y","Yeung YH"],"additional_accession":[]},"is_claimable":false,"name":"Versatile Synthesis of Multivalent Porphyrin-Peptide Conjugates by Direct Porphyrin Construction on Resin.","description":"Multifunctional porphyrin-peptide conjugates with different propensities for self-assembly into various supramolecular nanoarchitectures play important roles in advanced materials and biomedical research. However, preparing prefunctionalized core porphyrins by traditional low-yielding statistical synthesis and purifying them after peptide ligation through many rounds of HPLC purification is tedious and unsustainable. Herein, we report a novel integrated solid-phase synthetic protocol for the construction of porphyrin moieties from simple aldehydes and dipyrromethanes on resin-bound peptides directly to form mono-, cis/trans-di-, and trivalent porphyrin-peptide conjugates in a highly efficient and controllable manner; moreover, only single final-stage HPLC purification of the products is ne","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-19T04:48:42.459Z","creation":"2025-04-19T04:48:42.459Z"},"accession":"S-EPMC9543522","cross_references":{"pubmed":["35730925"],"doi":["10.1002/anie.202207532"]}}