biostudies-literatureUnknown37(7)Krismer FH. Lundbeck A/STeva Pharmaceutical Industries<h4>Background</h4>The Unified Multiple System Atrophy Rating Scale (UMSARS) is a commonly used semiquantitative rating scale to assess symptoms and measure disease progression in multiple system atrophy (MSA). However, it is currently incompletely understood which UMSARS items are the most sensitive to change and most relevant to the patient.<h4>Objective</h4>The objective of this study was to assess sensitivity to change and patient-centricity of single UMSARS items.<h4>Methods</h4>Data were taken from the European Multiple System Atrophy Study Group Natural History Study and the Rasagiline for Multiple System Atrophy trial. Sensitivity of change of an item of the UMSARS was assessed by calculation of a sensitivity-to-change ratio using its mean slope of progression divided by the standaMovement disorders : official journal of the Movement Disorder Society1425-1431https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543676biostudies-literatureSensitivity to Change and Patient-Centricity of the Unified Multiple System Atrophy Rating Scale Items: A Data-Driven Analysis.PMC9543676Krismer FGordon MFPoewe WRasagiline-for-Multiple System Atrophy InvestigatorsJonsson LEuropean Multiple System Atrophy Study Group Natural History Study InvestigatorsAstrom DOBerger AKSimonsen JWenning GKSeppi KfalseSensitivity to Change and Patient-Centricity of the Unified Multiple System Atrophy Rating Scale Items: A Data-Driven Analysis.<h4>Background</h4>The Unified Multiple System Atrophy Rating Scale (UMSARS) is a commonly used semiquantitative rating scale to assess symptoms and measure disease progression in multiple system atrophy (MSA). However, it is currently incompletely understood which UMSARS items are the most sensitive to change and most relevant to the patient.<h4>Objective</h4>The objective of this study was to assess sensitivity to change and patient-centricity of single UMSARS items.<h4>Methods</h4>Data were taken from the European Multiple System Atrophy Study Group Natural History Study and the Rasagiline for Multiple System Atrophy trial. Sensitivity of change of an item of the UMSARS was assessed by calculation of a sensitivity-to-change ratio using its mean slope of progression divided by the standa2022-01-01T00:00:00Z2022 Jul2025-04-22T12:09:02.242Z2025-04-06T00:12:38.662ZS-EPMC95436763533258210.1002/mds.28993