biostudies-literatureBohbot YBritish Heart FoundationMedical Research Council1253-1265https://www.ebi.ac.uk/biostudies/studies/S-EPMC9543970biostudies-literatureUnknown24(7)<h4>Aims</h4>To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry.<h4>Methods and results</h4>Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n = 698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10 mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p ≤ 0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CHEuropean journal of heart failureCharacteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry.PMC9543970CH/1996001/9454MC_UU_00017/3Martins COlivieri GMTulane CArnaiz de Las Revillas FFernandez-Golfin CAshikaga KPasciuta RBranea HSJimbei PSinan UYTaniguchi NGhadrdoost BGoehringer FWatanabe NGranillo Fernandez MMachacek SRizk HSeparovic-Hanzevacki JAgricola EFernandez Oses PJin-Oh CMoreo AYamazaki KLecoq EBenesco IRicafort GScheggi VAlterini BOuali SSkardal RGale CPPfafflin FGara ERajani RSengoku KGuffanti MAnguita MTenaglia RCarletti STrifunovic DLebras SCardim NMMahy SCitu IMAntit SLovric DCasalta JPSaijo YBaslib FElkentaoui SAl Habash OGhavidel AZahn RRiezebos RAthanasiou DCasha RIlic-Habensus EWeytjens 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JCDavid AYuichiro OFernandez-Hidalgo NBrasselet CCaillon JLe Berre RBartykowszki AAlcantara MHryniewiecki TRodrigues DMoreira DRodrigues AWind ABangher MCammilleri SPappas KAguero Balbin JVriend JMusca FSoens LFreitas PRoosens BPlonska-Gosciniak EMoreno AAlvaro MSalmo FAndor MMatskeplishvili SArnaiz Garcia AIribarren AWakami KKlein JRodrigus ITurrini FMisztal-Ogonowska MGastaldello NSilva CYGranada IReskovic-Luksic VPoh KKBansal MAlyavi BArmenis ISeno HChevalier EManolis AGunning MJonkaitiene RBrandt RLe Bihan DCrijns HJKong WKLacoste MFilipini EGulel OMilto AMichaux CPintassilgo IBraga JVelcean LARaissouni MRodriguez-Alvarez RPopescu IMisailidou SGarcia RIleri CPlein DStrahilevitz JSambola AGelape CLLorusso RLecompte ASPouliquen MCLopez-Rodriguez ECortez DSebag IAElgebaly OFarrugia JZvirblyte RCueff CSeabra DYuda SVillares Jimenez ABeauloye CBorgermann JTrofenciuc NMHernandez-Meneses MWallentin LZerva KSelton-Suty CIshizu TNakatani SMavrea AQuintana EKlinger STaborsky MElshiekh 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VOury CLe Tourneau TScarpellini PXuereb RGNavas Elorza EVidal BSuzuki GLakovic PTakanashi SFumarola FSparano CHagiwara NGarcia-Dorado DMikulcova MAthanassopoulos GMornos CHamodraka EPaelinck BEORP EURO-ENDO Registry Investigators GroupMarco FMaggioni APAinine KSavoure AHustache-Mathieu LGrassi LNaka KKucukoglu SOltolini CPiper CBlanes MHellner CLefevre BGaina VPetronio ASAlmela MFelix APeugnet FHuttin OFlecher EChandrasekaran BGoanta FKammoun SSandoval EAnzules NAlarcon CJoao GDel Pace SGuillen Marzo MPerschy LKoutsiari ADworakowski RGalrinho ADambrauskaite AChapuzet CHabib GAbd El-Nasser MRadano IRaevschi ETattevin PSusak SLee STolksdorf HBenyoussef SMateu LPoulimenos LFraiture Bvan Dongen EVarga AHolicka MTessonnier LBaratta PStohr ESpinar JRojek ACirin LFerrara DMaisterra OFalces CSera FGarcia Cuello LDetoc MJung EZayed YKilkowski CBudaj AMagne JSkulstad HGouvea ARamos AAl-Mallah MBeitnes JOPinto PPajoro UGruodyte GGonzalez Rico CLugo Adan JProta CZarger PBerastegui EGerminas ANDarabantiu DWahid ATeske APerez MTGoikoetxea JPelouch RMallia Azzopardi CCaruntu FQueiros CGohier SZakhama LKang DHYamamoto MYamamoto HMotoc AFruhauf ACLe Ven FRuiz-Zamora IBravo Amaro MPlastino MLRuozi NTolosana JMBayes-Genis AVieira MAttia NKnebel FTomescu MCCarmelo VVilela FAmsel BHristova KYiangou KAl Kholy AAzevedo JParvanescu TStante MBen Hlima MIsner CAtas HMarchetta SSengupta SMourali MSEmberson JBeleslin BWild CKrajinovic VStolk VDoss RMiyake MBenvenga RMPow Chon Long FAtkocaityte JWanounou MAshihara KKowalczyk EPuticiu MIChavanet PEl Hatimi SfalseCharacteristics, management, and outcomes of patients with left-sided infective endocarditis complicated by heart failure: a substudy of the ESC-EORP EURO-ENDO (European infective endocarditis) registry.<h4>Aims</h4>To evaluate the current management and survival of patients with left-sided infective endocarditis (IE) complicated by congestive heart failure (CHF) in the ESC-EORP European Endocarditis (EURO-ENDO) registry.<h4>Methods and results</h4>Among the 3116 patients enrolled in this prospective registry, 2449 (mean age: 60 years, 69% male) with left-sided (native or prosthetic) IE were included in this study. Patients with CHF (n = 698, 28.5%) were older, with more comorbidity and more severe valvular damage (mitro-aortic involvement, vegetations >10 mm and severe regurgitation/new prosthesis dehiscence) than those without CHF (all p ≤ 0.019). Patients with CHF experienced higher 30-day and 1-year mortality than those without (20.5% vs. 9.0% and 36.1% vs. 19.3%, respectively) and CH2022-01-01T00:00:00Z2022 Jul2026-03-31T11:54:45.175Z2025-04-04T20:04:10.161ZS-EPMC95439703550891510.1002/ejhf.2525