{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["130(4)"],"submitter":["Balta MG"],"pubmed_abstract":["Chronic inflammatory responses can inflict permanent damage to host tissues. Specialized pro-resolving mediators downregulate inflammation but also can have other functions. The aim of this study was to examine whether oral epithelial cells express the receptors FPR2/ALX and DRV1/GPR32, which bind RvD1<sub>n-3 DPA</sub> , a recently described pro-resolving mediator derived from omega-3 docosapentaenoic acid (DPA), and whether RvD1<sub>n-3 DPA</sub> exposure induced significant responses in these cells. Gingival biopsies were stained using antibodies to FPR2/ALX and DRV1/GPR32. Expression of FPR2/ALX and DRV1/GPR32 was examined in primary oral epithelial cells by qRT-PCR, flow cytometry, and immunofluorescence. The effect of RvD1<sub>n-3 DPA</sub> on intracellular calcium mobilization and t"],"journal":["European journal of oral sciences"],"pagination":["e12883"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544308"],"repository":["biostudies-literature"],"pubmed_title":["Expression and function of resolvin RvD1<sub>n-3 DPA</sub> receptors in oral epithelial cells."],"pmcid":["PMC9544308"],"pubmed_authors":["Baekkevold ES","Kuntziger TM","Balta MG","Vik A","Hansen TV","Schenck K","Tungen JE","Glaab E","Schreurs O","Blix IJS"],"additional_accession":[]},"is_claimable":false,"name":"Expression and function of resolvin RvD1<sub>n-3 DPA</sub> receptors in oral epithelial cells.","description":"Chronic inflammatory responses can inflict permanent damage to host tissues. Specialized pro-resolving mediators downregulate inflammation but also can have other functions. The aim of this study was to examine whether oral epithelial cells express the receptors FPR2/ALX and DRV1/GPR32, which bind RvD1<sub>n-3 DPA</sub> , a recently described pro-resolving mediator derived from omega-3 docosapentaenoic acid (DPA), and whether RvD1<sub>n-3 DPA</sub> exposure induced significant responses in these cells. Gingival biopsies were stained using antibodies to FPR2/ALX and DRV1/GPR32. Expression of FPR2/ALX and DRV1/GPR32 was examined in primary oral epithelial cells by qRT-PCR, flow cytometry, and immunofluorescence. The effect of RvD1<sub>n-3 DPA</sub> on intracellular calcium mobilization and t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-26T22:09:21.651Z","creation":"2025-04-06T17:04:58.657Z"},"accession":"S-EPMC9544308","cross_references":{"pubmed":["35808844"],"doi":["10.1111/eos.12883"]}}