biostudies-literatureUnknown130(4)Balta MGChronic inflammatory responses can inflict permanent damage to host tissues. Specialized pro-resolving mediators downregulate inflammation but also can have other functions. The aim of this study was to examine whether oral epithelial cells express the receptors FPR2/ALX and DRV1/GPR32, which bind RvD1_{n-3 DPA} , a recently described pro-resolving mediator derived from omega-3 docosapentaenoic acid (DPA), and whether RvD1_{n-3 DPA} exposure induced significant responses in these cells. Gingival biopsies were stained using antibodies to FPR2/ALX and DRV1/GPR32. Expression of FPR2/ALX and DRV1/GPR32 was examined in primary oral epithelial cells by qRT-PCR, flow cytometry, and immunofluorescence. The effect of RvD1_{n-3 DPA} on intracellular calcium mobilization and tEuropean journal of oral sciencese12883https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544308biostudies-literatureExpression and function of resolvin RvD1_{n-3 DPA} receptors in oral epithelial cells.PMC9544308Baekkevold ESKuntziger TMBalta MGVik AHansen TVSchenck KTungen JEGlaab ESchreurs OBlix IJSfalseExpression and function of resolvin RvD1_{n-3 DPA} receptors in oral epithelial cells.Chronic inflammatory responses can inflict permanent damage to host tissues. Specialized pro-resolving mediators downregulate inflammation but also can have other functions. The aim of this study was to examine whether oral epithelial cells express the receptors FPR2/ALX and DRV1/GPR32, which bind RvD1_{n-3 DPA} , a recently described pro-resolving mediator derived from omega-3 docosapentaenoic acid (DPA), and whether RvD1_{n-3 DPA} exposure induced significant responses in these cells. Gingival biopsies were stained using antibodies to FPR2/ALX and DRV1/GPR32. Expression of FPR2/ALX and DRV1/GPR32 was examined in primary oral epithelial cells by qRT-PCR, flow cytometry, and immunofluorescence. The effect of RvD1_{n-3 DPA} on intracellular calcium mobilization and t2022-01-01T00:00:00Z2022 Aug2025-04-26T22:09:21.651Z2025-04-06T17:04:58.657ZS-EPMC95443083580884410.1111/eos.12883