{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(40)"],"submitter":["Tang PC"],"pubmed_abstract":["Tumor innervation is a common phenomenon with unknown mechanism. Here, we discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis via a subset showing neuronal phenotypes and pain receptor expression associated with cancer-driven nocifensive behaviors. This subset is rich in lung adenocarcinoma associated with poorer prognosis. By elucidating the transcriptome dynamics of TAM with single-cell resolution, we discovered a phenomenon \"macrophage to neuron-like cell transition\" (MNT) for directly promoting tumoral neurogenesis, evidenced by macrophage depletion and fate-mapping study in lung carcinoma models. Encouragingly, we detected neuronal phenotypes and activities of the bone marrow-derived MNT cells (MNTs) in vitro. Adoptive transfer of MNTs"],"journal":["Science advances"],"pagination":["eabn5535"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544324"],"repository":["biostudies-literature"],"pubmed_title":["Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain."],"pmcid":["PMC9544324"],"pubmed_authors":["Lan HY","Chan AS","Lee TL","Tang PC","Lam EW","Zhang D","Li C","Leung KT","Ng CS","Chan MK","Ko H","Liao J","To KF","Jiang X","Ho YP","Tang PM","Cheng G","Huang XR","Chung JY"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain.","description":"Tumor innervation is a common phenomenon with unknown mechanism. Here, we discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis via a subset showing neuronal phenotypes and pain receptor expression associated with cancer-driven nocifensive behaviors. This subset is rich in lung adenocarcinoma associated with poorer prognosis. By elucidating the transcriptome dynamics of TAM with single-cell resolution, we discovered a phenomenon \"macrophage to neuron-like cell transition\" (MNT) for directly promoting tumoral neurogenesis, evidenced by macrophage depletion and fate-mapping study in lung carcinoma models. Encouragingly, we detected neuronal phenotypes and activities of the bone marrow-derived MNT cells (MNTs) in vitro. Adoptive transfer of MNTs","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T10:38:07.414Z","creation":"2025-02-18T23:58:15.896Z"},"accession":"S-EPMC9544324","cross_references":{"pubmed":["36206343"],"doi":["10.1126/sciadv.abn5535"]}}