{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Solas M"],"funding":["\"la Caixa\" Foundation","“la Caixa” Foundation","Consejería de Educación, Junta de Castilla y León","Agencia Estatal de Investigación"],"pagination":["e202207406"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(35)"],"pubmed_abstract":["The asymmetric synthesis of cyclopentachromenones from gold-catalyzed reaction of readily available skipped alkenynones is described. This cascade reaction involves an initial anti-Michael hydroarylation of the ynone moiety to form a gold-functionalized dialkenylketone intermediate, followed by a Nazarov cyclization that proceeds in an unprecedented enantioselective manner. Excellent enantiomeric ratios and chemical yields are obtained under mild reaction conditions."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Asymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov Cyclization: Enantioselective Access to Cyclopentenones."],"pmcid":["PMC9544548"],"funding_grant_id":["LCF/PR/PR18/51130007","BU049P20","CTQ2016-75023-C2-1P","PID2020-115789GB-C21","BU291P18"],"pubmed_authors":["Sanz R","Solas M","Suarez-Pantiga S"],"additional_accession":[]},"is_claimable":false,"name":"Asymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov Cyclization: Enantioselective Access to Cyclopentenones.","description":"The asymmetric synthesis of cyclopentachromenones from gold-catalyzed reaction of readily available skipped alkenynones is described. This cascade reaction involves an initial anti-Michael hydroarylation of the ynone moiety to form a gold-functionalized dialkenylketone intermediate, followed by a Nazarov cyclization that proceeds in an unprecedented enantioselective manner. Excellent enantiomeric ratios and chemical yields are obtained under mild reaction conditions.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T20:03:56.402Z","creation":"2025-04-04T20:03:56.402Z"},"accession":"S-EPMC9544548","cross_references":{"pubmed":["35785510"],"doi":["10.1002/anie.202207406"]}}