biostudies-literatureSolas M"la Caixa" Foundation“la Caixa” FoundationConsejería de Educación, Junta de Castilla y LeónAgencia Estatal de Investigacióne202207406https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544548biostudies-literatureUnknown61(35)The asymmetric synthesis of cyclopentachromenones from gold-catalyzed reaction of readily available skipped alkenynones is described. This cascade reaction involves an initial anti-Michael hydroarylation of the ynone moiety to form a gold-functionalized dialkenylketone intermediate, followed by a Nazarov cyclization that proceeds in an unprecedented enantioselective manner. Excellent enantiomeric ratios and chemical yields are obtained under mild reaction conditions.Angewandte Chemie (International ed. in English)Asymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov Cyclization: Enantioselective Access to Cyclopentenones.PMC9544548LCF/PR/PR18/51130007BU049P20CTQ2016-75023-C2-1PPID2020-115789GB-C21BU291P18Sanz RSolas MSuarez-Pantiga SfalseAsymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov Cyclization: Enantioselective Access to Cyclopentenones.The asymmetric synthesis of cyclopentachromenones from gold-catalyzed reaction of readily available skipped alkenynones is described. This cascade reaction involves an initial anti-Michael hydroarylation of the ynone moiety to form a gold-functionalized dialkenylketone intermediate, followed by a Nazarov cyclization that proceeds in an unprecedented enantioselective manner. Excellent enantiomeric ratios and chemical yields are obtained under mild reaction conditions.2022-01-01T00:00:00Z2022 Aug2025-04-04T20:03:56.402Z2025-04-04T20:03:56.402ZS-EPMC95445483578551010.1002/anie.202207406