{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(51)"],"submitter":["Deng H"],"funding":["China Scholarship Council","China Sponsorship Council","Max-Planck-Gesellschaft"],"pubmed_abstract":["The fine-tuning of metal-phosphine-catalyzed reactions relies largely on accessing ever more precisely tuned phosphine ligands by de-novo synthesis. Late-stage C-H functionalization and diversification of commercial phosphines offers rapid access to entire libraries of derivatives based on privileged scaffolds. But existing routes, relying on phosphorus-directed transformations, only yield functionalization of C sp2 -H bonds in a specific position relative to phosphorus. In contrast to phosphorus-directed strategies, herein we disclose an orthogonal functionalization strategy capable of introducing a range of substituents into previously inaccessible positions on arylphosphines. The strongly coordinating phosphine group acts solely as a bystander in the sterically controlled borylation of "],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pagination":["e202202074"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544633"],"repository":["biostudies-literature"],"pubmed_title":["Sterically Controlled Late-Stage Functionalization of Bulky Phosphines."],"pmcid":["PMC9544633"],"pubmed_authors":["Bengsch M","Tchorz N","Deng H","Neumann CN"],"additional_accession":[]},"is_claimable":false,"name":"Sterically Controlled Late-Stage Functionalization of Bulky Phosphines.","description":"The fine-tuning of metal-phosphine-catalyzed reactions relies largely on accessing ever more precisely tuned phosphine ligands by de-novo synthesis. Late-stage C-H functionalization and diversification of commercial phosphines offers rapid access to entire libraries of derivatives based on privileged scaffolds. But existing routes, relying on phosphorus-directed transformations, only yield functionalization of C sp2 -H bonds in a specific position relative to phosphorus. In contrast to phosphorus-directed strategies, herein we disclose an orthogonal functionalization strategy capable of introducing a range of substituents into previously inaccessible positions on arylphosphines. The strongly coordinating phosphine group acts solely as a bystander in the sterically controlled borylation of ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T20:04:09.208Z","creation":"2025-04-04T20:04:09.208Z"},"accession":"S-EPMC9544633","cross_references":{"pubmed":["35789048"],"doi":["10.1002/chem.202202074"]}}