{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang R"],"funding":["NIMH NIH HHS","Brain and Behavior Research Foundation","National Institute of Mental Health","Swedish Research Council","Lundbeck Foundation","National Institute of Child Health and Human Development"],"pagination":["442-458"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544642"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(5)"],"pubmed_abstract":["Among individuals with eating disorders (ED), those with co-occurring autism are often considered to have more severe presentations and poorer prognosis. However, previous findings have been contradictory and limited by small sample size and/or cross-sectional assessment of autistic traits. We examine the hypothesis that autism diagnosis and autism polygenic score (PGS) are associated with increased ED severity in a large ED cohort using a broad range of ED severity indicators. Our cohort included 3189 individuals (64 males) born 1977-2000 with current or previous anorexia nervosa who participated in the Anorexia Nervosa Genetics Initiative-Sweden (ANGI-SE) and for whom genotypes and linkage to national registers were available. We identified 134 (4.2%) individuals with registered autism d"],"journal":["European eating disorders review : the journal of the Eating Disorders Association"],"pubmed_title":["Association of autism diagnosis and polygenic scores with eating disorder severity."],"pmcid":["PMC9544642"],"funding_grant_id":["R276‐2018‐4581","R01HD095910, R01HD098732, R21HD105906-01A1","538‐2013‐8864","R276-2018-4581","R01HD095910, R01HD098732, R21HD105906‐01A1","R01MH120170, R01MH119084, R01MH118278, R01 MH124871","538-2013-8864"],"pubmed_authors":["Thornton LM","Bulik CM","Birgegard A","Landen M","Zhang R","Dinkler L","Fundin B"],"additional_accession":[]},"is_claimable":false,"name":"Association of autism diagnosis and polygenic scores with eating disorder severity.","description":"Among individuals with eating disorders (ED), those with co-occurring autism are often considered to have more severe presentations and poorer prognosis. However, previous findings have been contradictory and limited by small sample size and/or cross-sectional assessment of autistic traits. We examine the hypothesis that autism diagnosis and autism polygenic score (PGS) are associated with increased ED severity in a large ED cohort using a broad range of ED severity indicators. Our cohort included 3189 individuals (64 males) born 1977-2000 with current or previous anorexia nervosa who participated in the Anorexia Nervosa Genetics Initiative-Sweden (ANGI-SE) and for whom genotypes and linkage to national registers were available. We identified 134 (4.2%) individuals with registered autism d","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T04:50:27.324Z","creation":"2025-04-19T04:50:27.324Z"},"accession":"S-EPMC9544642","cross_references":{"pubmed":["35855524"],"doi":["10.1002/erv.2941"]}}