{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McCall SJ"],"funding":["Medical Research Council","University of Kentucky","French Health Ministry under its Clinical Research Hospital Program"],"pagination":["1676-1685"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544707"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["129(10)"],"pubmed_abstract":["<h4>Objective</h4>To compare the management and outcomes of women with placenta accreta spectrum (PAS) in France and the UK.<h4>Design</h4>Two population-based cohorts.<h4>Setting</h4>All obstetrician-led hospitals in the UK and maternity hospitals in eight French regions.<h4>Population</h4>A cohort of 219 women with PAS in France and a cohort of 154 women with PAS in the UK.<h4>Methods</h4>The management and outcomes of women with PAS were compared between the UK and France.<h4>Main outcome measures</h4>Median blood loss, severe postpartum haemorrhage (≥3 l), postpartum infection and damage to surrounding organs.<h4>Results</h4>The management of PAS differed between the two countries: a larger proportion of women with PAS in the UK had a caesarean hysterectomy compared with France (43% vs 26%, p < 0.001), whereas in France a larger proportion of women with PAS received a uterus-preserving approach compared with the UK (36% vs 19%, p < 0.001). The total median blood loss in the UK was 3 l (IQR 1.7-6.5 l), compared with 1 l (IQR 0.5-2.5 l) in France; more women with PAS had a severe postpartum haemorrhage (PPH) in the UK compared with women with PAS in France (58% vs 21%, p < 0.001) [Correction added on 06 May 2022, after first online publication: '24 hour' has been changed to 'total' in the preceding sentence]. There was no difference between the UK and French populations for postpartum infection or organ damage.<h4>Conclusions</h4>The UK and France have very different approaches to managing PAS, with more women in France receiving a uterine-conserving approach and more women in the UK undergoing caesarean hysterectomy. A life-threatening haemorrhage was more common in the UK than in France, which may be the result of differential management and/or the organisation of the healthcare systems. In women with placenta accreta spectrum, severe haemorrhage was more common in the UK than in France.<h4>Tweetable abstract</h4>In women with placenta accreta spectrum, severe haemorrhage was more common in the UK than in France."],"journal":["BJOG : an international journal of obstetrics and gynaecology"],"pubmed_title":["Placenta accreta spectrum - variations in clinical practice and maternal morbidity between the UK and France: a population-based comparative study."],"pmcid":["PMC9544707"],"funding_grant_id":["AOR12156"],"pubmed_authors":["Kayem G","Collins SL","Kurinczuk JJ","Knight M","Sentilhes L","McCall SJ","Ramakrishnan R","Deneux-Tharaux C","Seco A"],"additional_accession":[]},"is_claimable":false,"name":"Placenta accreta spectrum - variations in clinical practice and maternal morbidity between the UK and France: a population-based comparative study.","description":"<h4>Objective</h4>To compare the management and outcomes of women with placenta accreta spectrum (PAS) in France and the UK.<h4>Design</h4>Two population-based cohorts.<h4>Setting</h4>All obstetrician-led hospitals in the UK and maternity hospitals in eight French regions.<h4>Population</h4>A cohort of 219 women with PAS in France and a cohort of 154 women with PAS in the UK.<h4>Methods</h4>The management and outcomes of women with PAS were compared between the UK and France.<h4>Main outcome measures</h4>Median blood loss, severe postpartum haemorrhage (≥3 l), postpartum infection and damage to surrounding organs.<h4>Results</h4>The management of PAS differed between the two countries: a larger proportion of women with PAS in the UK had a caesarean hysterectomy compared with France (43% vs 26%, p < 0.001), whereas in France a larger proportion of women with PAS received a uterus-preserving approach compared with the UK (36% vs 19%, p < 0.001). The total median blood loss in the UK was 3 l (IQR 1.7-6.5 l), compared with 1 l (IQR 0.5-2.5 l) in France; more women with PAS had a severe postpartum haemorrhage (PPH) in the UK compared with women with PAS in France (58% vs 21%, p < 0.001) [Correction added on 06 May 2022, after first online publication: '24 hour' has been changed to 'total' in the preceding sentence]. There was no difference between the UK and French populations for postpartum infection or organ damage.<h4>Conclusions</h4>The UK and France have very different approaches to managing PAS, with more women in France receiving a uterine-conserving approach and more women in the UK undergoing caesarean hysterectomy. A life-threatening haemorrhage was more common in the UK than in France, which may be the result of differential management and/or the organisation of the healthcare systems. In women with placenta accreta spectrum, severe haemorrhage was more common in the UK than in France.<h4>Tweetable abstract</h4>In women with placenta accreta spectrum, severe haemorrhage was more common in the UK than in France.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T12:13:04.793Z","creation":"2025-04-06T00:15:20.052Z"},"accession":"S-EPMC9544707","cross_references":{"pubmed":["35384244"],"doi":["10.1111/1471-0528.17169"]}}