{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["112(2)"],"submitter":["You R"],"pubmed_abstract":["The stromal niche plays a pivotal role in AML chemoresistance and energy metabolism reprogramming is a hallmark of a tumor. 5'-Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor suppressing mammalian target of rapamycin complex 1 (mTORC1) activity. However, the role of AMPK-mTORC1 pathway on connecting AML cell energy metabolism reprogramming and chemoresistance induced by the bone marrow microenvironment (BMM) is not defined. Here, with a co-culture system that simulates the interaction between BMM and AML cells, it is shown that stromal contact led to a decreased sensitivity to chemotherapy accompanied by an increase of oxidative phosphorylation (OXPHOS) activity and mitochondrial ATP synthesis in AML cells. The increased OXPHOS activity and excessive A"],"journal":["Journal of leukocyte biology"],"pagination":["299-311"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544716"],"repository":["biostudies-literature"],"pubmed_title":["Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy."],"pmcid":["PMC9544716"],"pubmed_authors":["Liu J","Pan Z","Chen P","Wang B","Li D","Feng X","Huang H","Hou D","You R","Wang X","Kang L","Xiao Q"],"additional_accession":[]},"is_claimable":false,"name":"Bone marrow microenvironment drives AML cell OXPHOS addiction and AMPK inhibition to resist chemotherapy.","description":"The stromal niche plays a pivotal role in AML chemoresistance and energy metabolism reprogramming is a hallmark of a tumor. 5'-Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor suppressing mammalian target of rapamycin complex 1 (mTORC1) activity. However, the role of AMPK-mTORC1 pathway on connecting AML cell energy metabolism reprogramming and chemoresistance induced by the bone marrow microenvironment (BMM) is not defined. Here, with a co-culture system that simulates the interaction between BMM and AML cells, it is shown that stromal contact led to a decreased sensitivity to chemotherapy accompanied by an increase of oxidative phosphorylation (OXPHOS) activity and mitochondrial ATP synthesis in AML cells. The increased OXPHOS activity and excessive A","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-22T02:01:16.341Z","creation":"2025-04-05T20:11:53.966Z"},"accession":"S-EPMC9544716","cross_references":{"pubmed":["34927743"],"doi":["10.1002/JLB.6A0821-409RR"]}}