biostudies-literatureLiu YAgricultural Science and Technology Innovation ProgramChina Postdoctoral Science FoundationNational Natural Science Foundation of China114-131https://www.ebi.ac.uk/biostudies/studies/S-EPMC9544932biostudies-literatureUnknown236(1)Abscisic acid (ABA) receptors are considered as the targeted manipulation of ABA sensitivity and water productivity in plants. Regulation of their stability or activity will directly affect ABA signalling. Mitogen-activated protein kinase (MAPK) cascades link multiple environmental and plant developmental cues. However, the molecular mechanism of ABA signalling and MAPK cascade interaction remains largely elusive. TaMPK3 overexpression decreases drought tolerance and wheat sensitivity to ABA, significantly weakening ABA's inhibitory effects on growth. Under drought stress, overexpression lines show lower survival rates, shoot fresh weight and proline content, but higher malondialdehyde levels at seedling stage, as well as decreased grain width and 1000 grain weight in both glasshouse and fThe New phytologistMitogen-activated protein kinase TaMPK3 suppresses ABA response by destabilising TaPYL4 receptor in wheat.PMC9544932CAAS‐ZDRW2020022019M660886CAAS‐ZDRW20210931871624Li YTSun GZMa YZChen JChen MLiu YWYu TFCao XYZhou YBZhang JPLu ZWLiu YXu ZSZheng LfalseMitogen-activated protein kinase TaMPK3 suppresses ABA response by destabilising TaPYL4 receptor in wheat.Abscisic acid (ABA) receptors are considered as the targeted manipulation of ABA sensitivity and water productivity in plants. Regulation of their stability or activity will directly affect ABA signalling. Mitogen-activated protein kinase (MAPK) cascades link multiple environmental and plant developmental cues. However, the molecular mechanism of ABA signalling and MAPK cascade interaction remains largely elusive. TaMPK3 overexpression decreases drought tolerance and wheat sensitivity to ABA, significantly weakening ABA's inhibitory effects on growth. Under drought stress, overexpression lines show lower survival rates, shoot fresh weight and proline content, but higher malondialdehyde levels at seedling stage, as well as decreased grain width and 1000 grain weight in both glasshouse and f2022-01-01T00:00:00Z2022 Oct2025-04-22T01:55:05.208Z2025-04-05T20:08:56.805ZS-EPMC95449323571911010.1111/nph.18326