{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez-Ram-de-Viu P"],"funding":["Government of Aragón","Gobierno de Aragón"],"pagination":["1140-1150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545338"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(8)"],"pubmed_abstract":["New racemic vicinal amino alcohol derivatives with 4-benzylidenecyclohexane skeleton and axial chirality have been prepared. A preparatively easy and efficient protocol for resolution of the N-benzoylamino alcohol is described. Using a 250 × 20 mm (L × ID) Chiralpak® IA column, and the appropriate mixture of n-hexane/ethanol/chloroform as eluent, both enantiomers of N-benzoylamino alcohol 3 are obtained with >99% enantiomeric excess (ee) by successive injections of a solution of the racemic sample in chloroform. The obtained axially chiral vicinal amino alcohol is used to synthesize structurally novel bisoxazoline ligands in high yields."],"journal":["Chirality"],"pubmed_title":["Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands."],"pmcid":["PMC9545338"],"funding_grant_id":["E45_20R"],"pubmed_authors":["Lopez-Ram-de-Viu P","Diaz-de-Villegas MD","Galvez JA"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands.","description":"New racemic vicinal amino alcohol derivatives with 4-benzylidenecyclohexane skeleton and axial chirality have been prepared. A preparatively easy and efficient protocol for resolution of the N-benzoylamino alcohol is described. Using a 250 × 20 mm (L × ID) Chiralpak® IA column, and the appropriate mixture of n-hexane/ethanol/chloroform as eluent, both enantiomers of N-benzoylamino alcohol 3 are obtained with >99% enantiomeric excess (ee) by successive injections of a solution of the racemic sample in chloroform. The obtained axially chiral vicinal amino alcohol is used to synthesize structurally novel bisoxazoline ligands in high yields.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-05-29T19:02:48.045Z","creation":"2025-05-29T19:02:48.045Z"},"accession":"S-EPMC9545338","cross_references":{"pubmed":["35609966"],"doi":["10.1002/chir.23475"]}}