{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Azmanova M"],"funding":["Academy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial/the British Heart Foundation Springboard Award","Royal Society"],"pagination":["e202200259"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545474"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(18)"],"pubmed_abstract":["The synthesis, characterisation, and evaluation of the in vitro cytotoxicity of five maleonitriledithiolate-based ruthenium metal complexes bearing various phosphine ligands towards two ovarian cancer cell lines (A2780 and A2780cisR), one non-small-cell lung cancer cell line (H460) and one normal prostate cell line (PNT2) are presented herein. These 18-electron complexes were designed with four water-soluble phosphine ligands to increase the water-solubility character of the corresponding electron-deficient ruthenium complex which showed great in vitro promises, and triphenylphosphine for comparison. The complexes with triphenylphosphine-3,3',3''-trisulfonic acid and triphenylphosphine present similar cytotoxicity compared to the 16-electron precursor, with equal cytotoxicity to both A2780"],"journal":["Chembiochem : a European journal of chemical biology"],"pubmed_title":["Anticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation."],"pmcid":["PMC9545474"],"funding_grant_id":["RGF\\EA\\201001","SBF003\\1170","URF150295"],"pubmed_authors":["Azmanova M","Rafols L","Pitto-Barry A","Cooper PA","Shnyder SD","Seaton CC"],"additional_accession":[]},"is_claimable":false,"name":"Anticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation.","description":"The synthesis, characterisation, and evaluation of the in vitro cytotoxicity of five maleonitriledithiolate-based ruthenium metal complexes bearing various phosphine ligands towards two ovarian cancer cell lines (A2780 and A2780cisR), one non-small-cell lung cancer cell line (H460) and one normal prostate cell line (PNT2) are presented herein. These 18-electron complexes were designed with four water-soluble phosphine ligands to increase the water-solubility character of the corresponding electron-deficient ruthenium complex which showed great in vitro promises, and triphenylphosphine for comparison. The complexes with triphenylphosphine-3,3',3''-trisulfonic acid and triphenylphosphine present similar cytotoxicity compared to the 16-electron precursor, with equal cytotoxicity to both A2780","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-22T12:12:18.8Z","creation":"2025-04-06T00:15:07.857Z"},"accession":"S-EPMC9545474","cross_references":{"pubmed":["35838006"],"doi":["10.1002/cbic.202200259"]}}