biostudies-literatureAzmanova MAcademy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial/the British Heart Foundation Springboard AwardRoyal Societye202200259https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545474biostudies-literatureUnknown23(18)The synthesis, characterisation, and evaluation of the in vitro cytotoxicity of five maleonitriledithiolate-based ruthenium metal complexes bearing various phosphine ligands towards two ovarian cancer cell lines (A2780 and A2780cisR), one non-small-cell lung cancer cell line (H460) and one normal prostate cell line (PNT2) are presented herein. These 18-electron complexes were designed with four water-soluble phosphine ligands to increase the water-solubility character of the corresponding electron-deficient ruthenium complex which showed great in vitro promises, and triphenylphosphine for comparison. The complexes with triphenylphosphine-3,3',3''-trisulfonic acid and triphenylphosphine present similar cytotoxicity compared to the 16-electron precursor, with equal cytotoxicity to both A2780Chembiochem : a European journal of chemical biologyAnticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation.PMC9545474RGF\EA\201001SBF003\1170URF150295Azmanova MRafols LPitto-Barry ACooper PAShnyder SDSeaton CCfalseAnticancer Water-Soluble Organoruthenium Complexes: Synthesis and Preclinical Evaluation.The synthesis, characterisation, and evaluation of the in vitro cytotoxicity of five maleonitriledithiolate-based ruthenium metal complexes bearing various phosphine ligands towards two ovarian cancer cell lines (A2780 and A2780cisR), one non-small-cell lung cancer cell line (H460) and one normal prostate cell line (PNT2) are presented herein. These 18-electron complexes were designed with four water-soluble phosphine ligands to increase the water-solubility character of the corresponding electron-deficient ruthenium complex which showed great in vitro promises, and triphenylphosphine for comparison. The complexes with triphenylphosphine-3,3',3''-trisulfonic acid and triphenylphosphine present similar cytotoxicity compared to the 16-electron precursor, with equal cytotoxicity to both A27802022-01-01T00:00:00Z2022 Sep2025-04-22T12:12:18.8Z2025-04-06T00:15:07.857ZS-EPMC95454743583800610.1002/cbic.202200259