biostudies-literatureGundogdu BFoundation for the National Institutes of HealthComprehensive Cancer Center, University of Chicago Medical CenterNCI NIH HHSNIH HHS2298-2310https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545544biostudies-literatureUnknown88(5)<h4>Purpose</h4>To evaluate and quantify inter-directional and inter-acquisition variation in diffusion-weighted imaging (DWI) and emphasize signals that report restricted diffusion to enhance cancer conspicuity, while reducing the effects of local microscopic motion and magnetic field fluctuations.<h4>Methods</h4>Ten patients with biopsy-proven prostate cancer were studied under an Institutional Review Board-approved protocol. Individual acquisitions of DWI signal intensities were reconstructed to calculate inter-acquisition distributions and their statistics, which were compared for healthy versus cancer tissue. A method was proposed to detect and filter the acquisitions affected by motion-induced signal loss. First, signals that reflect restricted diffusion were separated from the acquiMagnetic resonance in medicineDirectional and inter-acquisition variability in diffusion-weighted imaging and editing for restricted diffusion.PMC95455441R41CA244056‐01A1R01 CA227036R01 CA17280R01 CA1227061S10OD018448‐01R41 CA244056P30 CA014599‐37P30 CA014599S10 OD018448Fan XOto AKarczmar GSGuo XYousuf AAntic TChatterjee APittman JMGiurcanu MLee GDevaraj ASzasz TMedved MGundogdu BEngelmann RfalseDirectional and inter-acquisition variability in diffusion-weighted imaging and editing for restricted diffusion.<h4>Purpose</h4>To evaluate and quantify inter-directional and inter-acquisition variation in diffusion-weighted imaging (DWI) and emphasize signals that report restricted diffusion to enhance cancer conspicuity, while reducing the effects of local microscopic motion and magnetic field fluctuations.<h4>Methods</h4>Ten patients with biopsy-proven prostate cancer were studied under an Institutional Review Board-approved protocol. Individual acquisitions of DWI signal intensities were reconstructed to calculate inter-acquisition distributions and their statistics, which were compared for healthy versus cancer tissue. A method was proposed to detect and filter the acquisitions affected by motion-induced signal loss. First, signals that reflect restricted diffusion were separated from the acqui2022-01-01T00:00:00Z2022 Nov2025-04-19T04:46:08.633Z2025-04-19T04:46:08.633ZS-EPMC95455443586126810.1002/mrm.29385