biostudies-literatureBaisley KAgence Nationale de Recherches sur le Sida et les Hépatites Virales922-928https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545558biostudies-literatureUnknown23(8)<h4>Objectives</h4>Population-based universal test and treat (UTT) trials have shown an impact on population-level virological suppression. We followed the ANRS 12249 TasP trial population for 6 years to determine whether the intervention had longer-term survival benefits.<h4>Methods</h4>The TasP trial was a cluster-randomized trial in South Africa from 2012 to 2016. All households were offered 6-monthly home-based HIV testing. Immediate antiretroviral therapy (ART) was offered through trial clinics to all people living with HIV (PLHIV) in intervention clusters and according to national guidelines in control clusters. After the trial, individuals attending the trial clinics were transferred to the public ART programme. Deaths were ascertained through annual demographic surveillance. RandomHIV medicineEarly HIV treatment and survival over six years of observation in the ANRS 12249 Treatment as Prevention Trial.PMC95455582011‐375Hanekom WBaisley KCollier DDreyer JDabis FIwuji CHerbst KSiedner MJOrne-Gliemann JMngomezulu TLarmarange JPlazy MfalseEarly HIV treatment and survival over six years of observation in the ANRS 12249 Treatment as Prevention Trial.<h4>Objectives</h4>Population-based universal test and treat (UTT) trials have shown an impact on population-level virological suppression. We followed the ANRS 12249 TasP trial population for 6 years to determine whether the intervention had longer-term survival benefits.<h4>Methods</h4>The TasP trial was a cluster-randomized trial in South Africa from 2012 to 2016. All households were offered 6-monthly home-based HIV testing. Immediate antiretroviral therapy (ART) was offered through trial clinics to all people living with HIV (PLHIV) in intervention clusters and according to national guidelines in control clusters. After the trial, individuals attending the trial clinics were transferred to the public ART programme. Deaths were ascertained through annual demographic surveillance. Random2022-01-01T00:00:00Z2022 Sep2025-04-19T04:50:27.323Z2025-04-19T04:50:27.323ZS-EPMC95455583521830010.1111/hiv.13263