{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["133(2)"],"submitter":["Kheirandish P"],"funding":["Federal Ministry for Digital and Economic Affairs","BIOMIN GmbH","National Foundation for Research, Technology and Development","Christian Doppler Forschungsgesellschaft"],"pubmed_abstract":["<h4>Aim</h4>This study aimed to characterize the critical points for determining the development of dysbiosis associated with feed intolerances and ruminal acidosis.<h4>Methods and results</h4>A metabologenomics approach was used to characterize dynamic microbial and metabolomics shifts using the rumen simulation technique (RUSITEC) by feeding native cornstarch (ST), chemically modified cornstarch (CMS), or sucrose (SU). SU and CMS elicited the most drastic changes as rapidly as 4 h after feeding. This was accompanied by a swift accumulation of d-lactate, and the decline of benzoic and malonic acid. A consistent increase in Bifidobacterium and Lactobacillus as well as a decrease in fibrolytic bacteria was observed for both CMS and ST after 24 h, indicating intolerances within the fibre deg"],"journal":["Journal of applied microbiology"],"pagination":["458-476"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545568"],"repository":["biostudies-literature"],"pubmed_title":["Characterization of microbial intolerances and ruminal dysbiosis towards different dietary carbohydrate sources using an in vitro model."],"pmcid":["PMC9545568"],"pubmed_authors":["Zebeli Q","Pacifico C","Sener-Aydemir A","Petri RM","Kheirandish P","Schwartz-Zimmermann HE","Berthiller F"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of microbial intolerances and ruminal dysbiosis towards different dietary carbohydrate sources using an in vitro model.","description":"<h4>Aim</h4>This study aimed to characterize the critical points for determining the development of dysbiosis associated with feed intolerances and ruminal acidosis.<h4>Methods and results</h4>A metabologenomics approach was used to characterize dynamic microbial and metabolomics shifts using the rumen simulation technique (RUSITEC) by feeding native cornstarch (ST), chemically modified cornstarch (CMS), or sucrose (SU). SU and CMS elicited the most drastic changes as rapidly as 4 h after feeding. This was accompanied by a swift accumulation of d-lactate, and the decline of benzoic and malonic acid. A consistent increase in Bifidobacterium and Lactobacillus as well as a decrease in fibrolytic bacteria was observed for both CMS and ST after 24 h, indicating intolerances within the fibre deg","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-04-08T18:26:04.459Z","creation":"2025-02-19T01:28:10.473Z"},"accession":"S-EPMC9545568","cross_references":{"pubmed":["35396778"],"doi":["10.1111/jam.15573"]}}