biostudies-literatureKontsioti EAstraZenecaEngineering and Physical Sciences Research Council4067-4079https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545693biostudies-literatureUnknown88(9)<h4>Aims</h4>The aim of this study was to explore the level of agreement on drug-drug interaction (DDI) information listed in three major online drug information resources (DIRs) in terms of: (1) interacting drug pairs; (2) severity rating; (3) evidence rating; and (4) clinical management recommendations.<h4>Methods</h4>We extracted information from the British National Formulary (BNF), Thesaurus and Micromedex. Following drug name normalisation, we estimated the overlap of the DIRs in terms of DDI. We annotated clinical management recommendations either manually, where possible, or through application of a machine learning algorithm.<h4>Results</h4>The DIRs contained 51 481 (BNF), 38 037 (Thesaurus) and 65 446 (Micromedex) drug pairs involved in DDIs. The number of common DDIs across the British journal of clinical pharmacologySimilarity and consistency assessment of three major online drug-drug interaction resources.PMC95456931959810EP/R51231X/1Maskell SDutta BBensalem AKontsioti EPirmohamed MfalseSimilarity and consistency assessment of three major online drug-drug interaction resources.<h4>Aims</h4>The aim of this study was to explore the level of agreement on drug-drug interaction (DDI) information listed in three major online drug information resources (DIRs) in terms of: (1) interacting drug pairs; (2) severity rating; (3) evidence rating; and (4) clinical management recommendations.<h4>Methods</h4>We extracted information from the British National Formulary (BNF), Thesaurus and Micromedex. Following drug name normalisation, we estimated the overlap of the DIRs in terms of DDI. We annotated clinical management recommendations either manually, where possible, or through application of a machine learning algorithm.<h4>Results</h4>The DIRs contained 51 481 (BNF), 38 037 (Thesaurus) and 65 446 (Micromedex) drug pairs involved in DDIs. The number of common DDIs across the 2022-01-01T00:00:00Z2022 Sep2025-04-26T22:08:55.604Z2025-02-19T01:02:52.143ZS-EPMC95456933536221410.1111/bcp.15341