{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["42(10)"],"submitter":["Wong ET"],"funding":["Altria Client Services LLC","Philip Morris Products S.A."],"pubmed_abstract":["Most flavors used in e-liquids are generally recognized as safe for oral consumption, but their potential effects when inhaled are not well characterized. In vivo inhalation studies of flavor ingredients in e-liquids are scarce. A structure-based grouping approach was used to select 38 flavor group representatives (FGR) on the basis of known and in silico-predicted toxicological data. These FGRs were combined to create prototype e-liquid formulations and tested against cigarette smoke (CS) in a 5-week inhalation study. Female A/J mice were whole-body exposed for 6 h/day, 5 days/week, for 5 weeks to air, mainstream CS, or aerosols from (1) test formulations containing propylene glycol (PG), vegetable glycerol (VG), nicotine (N; 2% w/w), and flavor (F) mixtures at low (4.6% w/w), medium (9.3"],"journal":["Journal of applied toxicology : JAT"],"pagination":["1701-1722"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545811"],"repository":["biostudies-literature"],"pubmed_title":["Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice."],"pmcid":["PMC9545811"],"pubmed_authors":["Moine F","Ashutosh K","Diana P","Tung CK","Smith C","Chua CS","Sciuscio D","Glabasnia A","Hoeng J","Vanscheeuwijck P","Piault R","Ivanov N","Lee KM","Merg C","Peitsch M","Corciulo M","Wong ET","Luettich K","Leroy P","Cammack L","Chia C"],"additional_accession":[]},"is_claimable":false,"name":"Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice.","description":"Most flavors used in e-liquids are generally recognized as safe for oral consumption, but their potential effects when inhaled are not well characterized. In vivo inhalation studies of flavor ingredients in e-liquids are scarce. A structure-based grouping approach was used to select 38 flavor group representatives (FGR) on the basis of known and in silico-predicted toxicological data. These FGRs were combined to create prototype e-liquid formulations and tested against cigarette smoke (CS) in a 5-week inhalation study. Female A/J mice were whole-body exposed for 6 h/day, 5 days/week, for 5 weeks to air, mainstream CS, or aerosols from (1) test formulations containing propylene glycol (PG), vegetable glycerol (VG), nicotine (N; 2% w/w), and flavor (F) mixtures at low (4.6% w/w), medium (9.3","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T20:04:42.985Z","creation":"2025-04-04T20:04:42.985Z"},"accession":"S-EPMC9545811","cross_references":{"pubmed":["35543240"],"doi":["10.1002/jat.4338"]}}