{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sparks AM"],"funding":["European Research Council","Natural Environment Research Council","Royal Society","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["4607-4621"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545857"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(18)"],"pubmed_abstract":["Vitamin D has a well-established role in skeletal health and is increasingly linked to chronic disease and mortality in humans and companion animals. Despite the clear significance of vitamin D for health and obvious implications for fitness under natural conditions, no longitudinal study has tested whether the circulating concentration of vitamin D is under natural selection in the wild. Here, we show that concentrations of dietary-derived vitamin D<sub>2</sub> and endogenously produced vitamin D<sub>3</sub>  metabolites are heritable and largely polygenic in a wild population of Soay sheep (Ovis aries). Vitamin D<sub>2</sub>  status was positively associated with female adult survival, and vitamin D<sub>3</sub>  status predicted female fecundity in particular, good environment years when"],"journal":["Molecular ecology"],"pubmed_title":["Vitamin D status is heritable and under environment-dependent selection in the wild."],"pmcid":["PMC9545857"],"funding_grant_id":["098493/Z/12/Z","250098","EC 250098 WEG","NE/R011109/1","UF150448","BB/H021868/1"],"pubmed_authors":["Berry J","Mellanby RJ","Pemberton JM","Pilkington JG","Sparks AM","Johnston SE","Handel I","Nussey DH"],"additional_accession":[]},"is_claimable":false,"name":"Vitamin D status is heritable and under environment-dependent selection in the wild.","description":"Vitamin D has a well-established role in skeletal health and is increasingly linked to chronic disease and mortality in humans and companion animals. Despite the clear significance of vitamin D for health and obvious implications for fitness under natural conditions, no longitudinal study has tested whether the circulating concentration of vitamin D is under natural selection in the wild. Here, we show that concentrations of dietary-derived vitamin D<sub>2</sub> and endogenously produced vitamin D<sub>3</sub>  metabolites are heritable and largely polygenic in a wild population of Soay sheep (Ovis aries). Vitamin D<sub>2</sub>  status was positively associated with female adult survival, and vitamin D<sub>3</sub>  status predicted female fecundity in particular, good environment years when","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-28T04:42:06.061Z","creation":"2024-11-21T06:46:16.519Z"},"accession":"S-EPMC9545857","cross_references":{"pubmed":["34888965"],"doi":["10.1111/mec.16318"]}}