biostudies-literatureUnknown63(7)Arrotta KCleveland Clinic Foundation<h4>Objective</h4>Neuropsychological profiles are heterogeneous both across and within epilepsy syndromes, but especially in frontal lobe epilepsy (FLE), which has complex semiology and epileptogenicity. This study aimed to characterize the cognitive heterogeneity within FLE by identifying cognitive phenotypes and determining their demographic and clinical characteristics.<h4>Method</h4>One hundred and six patients (age 16-66; 44% female) with FLE completed comprehensive neuropsychological testing, including measures within five cognitive domains: language, attention, executive function, processing speed, and verbal/visual learning. Patients were categorized into one of four phenotypes based on the number of impaired domains. Patterns of domain impairment and clinical and demographic charaEpilepsia1671-1681https://www.ebi.ac.uk/biostudies/studies/S-EPMC9545860biostudies-literatureCognitive phenotypes in frontal lobe epilepsy.PMC9545860McDonald CRBarr WBBusch RMArrotta KSundar SKondylis EReyes AKaestner EBingaman WSarmey NNajm IHermann BPfalseCognitive phenotypes in frontal lobe epilepsy.<h4>Objective</h4>Neuropsychological profiles are heterogeneous both across and within epilepsy syndromes, but especially in frontal lobe epilepsy (FLE), which has complex semiology and epileptogenicity. This study aimed to characterize the cognitive heterogeneity within FLE by identifying cognitive phenotypes and determining their demographic and clinical characteristics.<h4>Method</h4>One hundred and six patients (age 16-66; 44% female) with FLE completed comprehensive neuropsychological testing, including measures within five cognitive domains: language, attention, executive function, processing speed, and verbal/visual learning. Patients were categorized into one of four phenotypes based on the number of impaired domains. Patterns of domain impairment and clinical and demographic chara2022-01-01T00:00:00Z2022 Jul2025-04-19T04:49:44.847Z2025-04-19T04:49:44.847ZS-EPMC95458603542917410.1111/epi.17260