{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lorthe E"],"funding":["National Research Agency","PREMUP Foundation","Fondation pour la Recherche Medicale","National Institute of Health and Medical Research (INSERM)","National Solidarity Fund for Autonomy (CNSA)","French Health Ministry","Fondation de France","National Institute of Cancer","Universite de Geneve","French Institute of Public Health Research/Institute of Public Health","Fondation des Treilles"],"pagination":["1560-1573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546066"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["129(9)"],"pubmed_abstract":["<h4>Objective</h4>To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.<h4>Design</h4>Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.<h4>Setting</h4>France, 2011.<h4>Sample</h4>We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation "],"journal":["BJOG : an international journal of obstetrics and gynaecology"],"pubmed_title":["Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort."],"pmcid":["PMC9546066"],"funding_grant_id":["Grant 00050329","SPF 20160936356","Grand Prix R18202KK","IRESP TGIR 2009-01","ANR-11-EQPX-0038"],"pubmed_authors":["Ramousset C","Badessi A","Schmitz T","Sagot P","Diguisto C","Maisonneuve E","Bedu A","Samperiz S","Bahans C","Chalons S","Hilpert L","Ramful D","Beuchee A","Morel O","Debeir M","Carbonne B","Roze JC","Mitanchez D","Krim G","Favre A","Granier M","Coquelin A","Cambonie G","Monier I","Khoshnood B","Rouget F","Charkaluk ML","Ego A","Balamou C","Thiriez G","Poulichet A","Pladys P","Boulot P","Langer B","Gras-Le Guen C","Duffaut C","Roudaut S","Bonet M","Arnaud C","Leguen A","Boileau P","Tosello B","Lecomte B","Matis J","Vieux R","Branger B","Laurence PL","Lorthe E","Pignol J","Hascoet JM","D'Ercole C","Claris O","Reboul L","Tran D","Burguet A","Blanc J","Goffinet F","Simeoni U","Dupuy RP","Morville P","Jarreau PH","Lemery D","Rubio-Gurung S","Gouyon JB","Fresson J","Khemache K","Picaud JC","Guillois B","Toure Y","Durrmeyer X","Durox M","Robillard PY","Costedoat MJ","Gascoin G","Sizun J","Rosenthal JM","Astruc D","Colas N","Couvreur S","Milton A","Rannaud A","Marchand-Martin L","Dreyfus M","EPIPAGE-2 Obstetric Writing Group","Blondel B","Desplanches T","Joly-Pedespan L","Torchin H","Kaminski M","Benhammou V","Charlier C","Rouger V","Vayssiere C","Barbier C","Rousseau J","Truffert P","Daude H","Coline E","Favreau A","Dupont C","Saurel-Cubizolles MJ","Foix L'Helias L","Vendittelli F","Alberge C","Cornu L","Gire C","Verriere V","Baby B","Bongain A","Bednarek N","Kayem G","Pierrat V","Akowanou S","Moras R","Charlot F","Binet MH","Patural H","Subtil D","Tsaoussis N","Mons F","Janky E","Marpeau L","Gondry J","Kuhn P","Delorme P","Brinis A","Marret S","Baron M","Ancel PY","Beucher G","Chabanier P","Morgan A","Zeitlin J","Letouzey M","Hernandorena X","Debillon T","Saliba E","Baud O","Sentilhes L","Soupre D","Ayoubi M","Joly N","Cans C","Lebeaux C","Deschamps M","Winer N"],"additional_accession":[]},"is_claimable":false,"name":"Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks' gestation: Perinatal and 2-year outcomes in the EPIPAGE-2 cohort.","description":"<h4>Objective</h4>To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.<h4>Design</h4>Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.<h4>Setting</h4>France, 2011.<h4>Sample</h4>We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-22T01:58:16.432Z","creation":"2025-04-05T20:10:09.669Z"},"accession":"S-EPMC9546066","cross_references":{"pubmed":["34954867"],"doi":["10.1111/1471-0528.17081"]}}