biostudies-literatureAoki RJapan Agency for Medical Research and DevelopmentMinistry of Education, Culture, Sports, Science and TechnologyFujita Health UniversityJapan Society for the Promotion of Science361-366https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546074biostudies-literatureUnknown76(8)<h4>Aim</h4>The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared genetic components between these disorders based on multipopulation data sets.<h4>Methods</h4>We used two data sets for East Asian (EAS) and European (EUR) samples. SCZ data was based on the Psychiatric Genomics Consortium Asia with our own genome-wide association study for EAS and Psychiatric Genomics Consortium for EUR. Nonpsychiatric data (20 binary traits [mainly nonpsychiatric complex disorders] and 34 quantitative traits [mainly laboratory examinations and physical characteristics]) were obtained from Biobank Japan and UK Biobank for EAS and EUR samples, respectively. To evaluate genetic correlation, linkage disequilibrium score regressioPsychiatry and clinical neurosciencesShared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets.PMC9546074JP21H02854JP21tm0424220Private University Research Branding ProjectJP20km0405201JP20km0405208JP17H04251JP18K15497JP21wm0425008JP20dm0107097JP21wm0525024JP21K07490Ashizawa TSaito TIto KShimasaki AIkeda MAoki RIwata NNinomiya KfalseShared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets.<h4>Aim</h4>The genetic relationship between schizophrenia (SCZ) and other nonpsychiatric disorders remains largely unknown. We examined the shared genetic components between these disorders based on multipopulation data sets.<h4>Methods</h4>We used two data sets for East Asian (EAS) and European (EUR) samples. SCZ data was based on the Psychiatric Genomics Consortium Asia with our own genome-wide association study for EAS and Psychiatric Genomics Consortium for EUR. Nonpsychiatric data (20 binary traits [mainly nonpsychiatric complex disorders] and 34 quantitative traits [mainly laboratory examinations and physical characteristics]) were obtained from Biobank Japan and UK Biobank for EAS and EUR samples, respectively. To evaluate genetic correlation, linkage disequilibrium score regressio2022-01-01T00:00:00Z2022 Aug2025-04-22T12:08:36.408Z2025-04-06T00:13:00.984ZS-EPMC95460743553616010.1111/pcn.13372