{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["110(10)"],"submitter":["de la Harpe KM"],"funding":["National research Foundation (NRF)","National Research Foundation"],"pubmed_abstract":["In this research, a novel bioabsorbable suture that is, monofilament and capable of localized drug delivery, was developed from a combination of natural biopolymers that where not previously applied for this purpose. The optimized suture formulation comprised of sodium alginate (6% wt/vol), pectin (0.1% wt/vol), and gelatin (3% wt/vol), in the presence of glycerol (4% vol/vol) which served as a plasticizer. The monofilament bioabsorbable sutures where synthesized via in situ ionic crosslinking in a barium chloride solution (2% wt/vol). The resulting suture was characterized in terms of mechanical properties, morphology, swelling, degradation, drug release, and biocompatibility, in addition to Fourier-transform infrared (FTIR) spectroscopy, Powder X-ray Diffraction (PXRD) and Differential S"],"journal":["Journal of biomedical materials research. Part B, Applied biomaterials"],"pagination":["2189-2210"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546231"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of a novel monofilament bioabsorbable suture for biomedical applications."],"pmcid":["PMC9546231"],"pubmed_authors":["Choonara YE","Marimuthu T","de la Harpe KM","Kondiah PPD","Kumar P","Ubanako P"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of a novel monofilament bioabsorbable suture for biomedical applications.","description":"In this research, a novel bioabsorbable suture that is, monofilament and capable of localized drug delivery, was developed from a combination of natural biopolymers that where not previously applied for this purpose. The optimized suture formulation comprised of sodium alginate (6% wt/vol), pectin (0.1% wt/vol), and gelatin (3% wt/vol), in the presence of glycerol (4% vol/vol) which served as a plasticizer. The monofilament bioabsorbable sutures where synthesized via in situ ionic crosslinking in a barium chloride solution (2% wt/vol). The resulting suture was characterized in terms of mechanical properties, morphology, swelling, degradation, drug release, and biocompatibility, in addition to Fourier-transform infrared (FTIR) spectroscopy, Powder X-ray Diffraction (PXRD) and Differential S","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T12:16:54.265Z","creation":"2025-04-06T00:14:03.19Z"},"accession":"S-EPMC9546231","cross_references":{"pubmed":["35373911"],"doi":["10.1002/jbm.b.35069"]}}