biostudies-literatureUnknown110(10)de la Harpe KMNational research Foundation (NRF)National Research FoundationIn this research, a novel bioabsorbable suture that is, monofilament and capable of localized drug delivery, was developed from a combination of natural biopolymers that where not previously applied for this purpose. The optimized suture formulation comprised of sodium alginate (6% wt/vol), pectin (0.1% wt/vol), and gelatin (3% wt/vol), in the presence of glycerol (4% vol/vol) which served as a plasticizer. The monofilament bioabsorbable sutures where synthesized via in situ ionic crosslinking in a barium chloride solution (2% wt/vol). The resulting suture was characterized in terms of mechanical properties, morphology, swelling, degradation, drug release, and biocompatibility, in addition to Fourier-transform infrared (FTIR) spectroscopy, Powder X-ray Diffraction (PXRD) and Differential SJournal of biomedical materials research. Part B, Applied biomaterials2189-2210https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546231biostudies-literatureSynthesis of a novel monofilament bioabsorbable suture for biomedical applications.PMC9546231Choonara YEMarimuthu Tde la Harpe KMKondiah PPDKumar PUbanako PfalseSynthesis of a novel monofilament bioabsorbable suture for biomedical applications.In this research, a novel bioabsorbable suture that is, monofilament and capable of localized drug delivery, was developed from a combination of natural biopolymers that where not previously applied for this purpose. The optimized suture formulation comprised of sodium alginate (6% wt/vol), pectin (0.1% wt/vol), and gelatin (3% wt/vol), in the presence of glycerol (4% vol/vol) which served as a plasticizer. The monofilament bioabsorbable sutures where synthesized via in situ ionic crosslinking in a barium chloride solution (2% wt/vol). The resulting suture was characterized in terms of mechanical properties, morphology, swelling, degradation, drug release, and biocompatibility, in addition to Fourier-transform infrared (FTIR) spectroscopy, Powder X-ray Diffraction (PXRD) and Differential S2022-01-01T00:00:00Z2022 Oct2025-04-22T12:16:54.265Z2025-04-06T00:14:03.19ZS-EPMC95462313537391110.1002/jbm.b.35069