biostudies-literatureUnknown30(7)de Groot JM<h4>Objective</h4>Nonalcoholic fatty liver disease (NAFLD) has a different prevalence in adults from different ethnic groups. This study examined whether these ethnic differences originate in early life and could be explained by early-life factors.<h4>Methods</h4>This observational study was embedded in a population-based prospective cohort study from fetal life onward among 2,570 children born in Rotterdam, the Netherlands. Information about prepregnancy, pregnancy, and childhood factors, as well as childhood BMI, was obtained from questionnaires and physical examinations. Liver fat was assessed by magnetic resonance imaging at age 10 years.<h4>Results</h4>Median liver fat fraction was 2.0% (95% CI: 1.2%-5.3%), and NAFLD prevalence was 2.8%. Children from a Turkish background had the highObesity (Silver Spring, Md.)1472-1482https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546249biostudies-literatureEthnic disparities in liver fat accumulation in school-aged children.PMC9546249Santos SJaddoe VWVGeurtsen MLde Groot JMfalseEthnic disparities in liver fat accumulation in school-aged children.<h4>Objective</h4>Nonalcoholic fatty liver disease (NAFLD) has a different prevalence in adults from different ethnic groups. This study examined whether these ethnic differences originate in early life and could be explained by early-life factors.<h4>Methods</h4>This observational study was embedded in a population-based prospective cohort study from fetal life onward among 2,570 children born in Rotterdam, the Netherlands. Information about prepregnancy, pregnancy, and childhood factors, as well as childhood BMI, was obtained from questionnaires and physical examinations. Liver fat was assessed by magnetic resonance imaging at age 10 years.<h4>Results</h4>Median liver fat fraction was 2.0% (95% CI: 1.2%-5.3%), and NAFLD prevalence was 2.8%. Children from a Turkish background had the high2022-01-01T00:00:00Z2022 Jul2025-04-19T04:45:45.087Z2025-04-19T04:45:45.087ZS-EPMC95462493578547610.1002/oby.23478