biostudies-literatureUnknown128(19)Bargon CASt. Antonius Ziekenhuis<h4>Background</h4>Oncological safety of different types and timings of PMBR after breast cancer remains controversial. Lack of stratified risk assessment in literature makes current clinical and shared decision-making complex. This is the first systematic review and meta-analysis to evaluate differences in oncological outcomes after immediate versus delayed postmastectomy breast reconstruction (PMBR) for autologous and implant-based PMBR separately.<h4>Methods</h4>A systematic literature search was performed in MEDLINE, Cochrane Library, and Embase. The Cochrane Collaboration Handbook and Meta-analysis Of Observational Studies in Epidemiology checklist were followed for data abstraction. Variability in point estimates attributable to heterogeneity was assessed using I² -statistCancer3449-3469https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546326biostudies-literatureBreast cancer recurrence after immediate and delayed postmastectomy breast reconstruction-A systematic review and meta-analysis.PMC9546326Ikinci MBraakenburg ADoeksen ABargon CAYoung-Afat DARakhorst HAMureau MAMVerkooijen HMfalseBreast cancer recurrence after immediate and delayed postmastectomy breast reconstruction-A systematic review and meta-analysis.<h4>Background</h4>Oncological safety of different types and timings of PMBR after breast cancer remains controversial. Lack of stratified risk assessment in literature makes current clinical and shared decision-making complex. This is the first systematic review and meta-analysis to evaluate differences in oncological outcomes after immediate versus delayed postmastectomy breast reconstruction (PMBR) for autologous and implant-based PMBR separately.<h4>Methods</h4>A systematic literature search was performed in MEDLINE, Cochrane Library, and Embase. The Cochrane Collaboration Handbook and Meta-analysis Of Observational Studies in Epidemiology checklist were followed for data abstraction. Variability in point estimates attributable to heterogeneity was assessed using I² -statist2022-01-01T00:00:00Z2022 Oct2025-04-22T01:51:43.005Z2025-04-05T20:09:59.604ZS-EPMC95463263589493610.1002/cncr.34393