{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wakamatsu K"],"funding":["Japan Society for the Promotion of Science"],"pagination":["117-125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546339"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["42(2)"],"pubmed_abstract":["Evidence showing the functional significance of the choroid plexus is accumulating. Although it is clinically well-known that calcification is frequently seen in the choroid plexus of aged human brains, it is unclear why calcification occurs in the aged choroid plexus and what exert effects on the calcification has. In this study, immunohistochemical localizations of collagens and other molecules related to fibrosis or calcification were investigated on the choroid plexus of autopsied human brains. Densely fibrous or calcified materials were located in the stroma just below the epithelial cells of the choroid plexus of all human brains examined. Immunoreactivity for collagen type I was identified in the stroma just below the epithelial cells, consistent with the densely fibrous or calcifie"],"journal":["Neuropathology : official journal of the Japanese Society of Neuropathology"],"pubmed_title":["Immunohistochemical expression of osteopontin and collagens in choroid plexus of human brains."],"pmcid":["PMC9546339"],"funding_grant_id":["17K08788","20K16550","20K16193","19K07508"],"pubmed_authors":["Ueno M","Wakamatsu K","Chiba Y","Matsumoto K","Kawauchi M","Uemura N","Murakami R","Miyai Y","Yanase K"],"additional_accession":[]},"is_claimable":false,"name":"Immunohistochemical expression of osteopontin and collagens in choroid plexus of human brains.","description":"Evidence showing the functional significance of the choroid plexus is accumulating. Although it is clinically well-known that calcification is frequently seen in the choroid plexus of aged human brains, it is unclear why calcification occurs in the aged choroid plexus and what exert effects on the calcification has. In this study, immunohistochemical localizations of collagens and other molecules related to fibrosis or calcification were investigated on the choroid plexus of autopsied human brains. Densely fibrous or calcified materials were located in the stroma just below the epithelial cells of the choroid plexus of all human brains examined. Immunoreactivity for collagen type I was identified in the stroma just below the epithelial cells, consistent with the densely fibrous or calcifie","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T01:58:57.986Z","creation":"2025-04-05T20:10:24.412Z"},"accession":"S-EPMC9546339","cross_references":{"pubmed":["34964160"],"doi":["10.1111/neup.12791"]}}