{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sengupta S"],"funding":["Deutsche Forschungsgemeinschaft","Deutsche Bundesstiftung Umwelt"],"pagination":["e202201359"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546396"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(50)"],"pubmed_abstract":["The in situ Grignard Metalation Method (iGMM) is a straightforward one-pot procedure to quickly produce multigram amounts of Hauser bases R<sub>2</sub> N-MgBr which are valuable and vastly used metalation reagents and novel electrolytes for magnesium batteries. During addition of bromoethane to a suspension of Mg metal and secondary amine at room temperature in an ethereal solvent, a smooth reaction yields R<sub>2</sub> N-MgBr under evolution of ethane within a few hours. A Schlenk equilibrium is operative, interconverting the Hauser bases into their solvated homoleptic congeners Mg(NR<sub>2</sub> )<sub>2</sub> and MgBr<sub>2</sub> depending on the solvent. Scope and preconditions are studied, and side reactions limiting the yield have been investigated. DOSY NMR experiments and X-ray crys"],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["In Situ Grignard Metalation Method for the Synthesis of Hauser Bases."],"pmcid":["PMC9546396"],"funding_grant_id":["INST 275/442-1 FUGG","20018/578"],"pubmed_authors":["Gorls H","Krieck S","Schuler P","Sengupta S","Westerhausen M","Liebing P"],"additional_accession":[]},"is_claimable":false,"name":"In Situ Grignard Metalation Method for the Synthesis of Hauser Bases.","description":"The in situ Grignard Metalation Method (iGMM) is a straightforward one-pot procedure to quickly produce multigram amounts of Hauser bases R<sub>2</sub> N-MgBr which are valuable and vastly used metalation reagents and novel electrolytes for magnesium batteries. During addition of bromoethane to a suspension of Mg metal and secondary amine at room temperature in an ethereal solvent, a smooth reaction yields R<sub>2</sub> N-MgBr under evolution of ethane within a few hours. A Schlenk equilibrium is operative, interconverting the Hauser bases into their solvated homoleptic congeners Mg(NR<sub>2</sub> )<sub>2</sub> and MgBr<sub>2</sub> depending on the solvent. Scope and preconditions are studied, and side reactions limiting the yield have been investigated. DOSY NMR experiments and X-ray crys","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-05T20:11:17.638Z","creation":"2025-04-05T20:11:17.638Z"},"accession":"S-EPMC9546396","cross_references":{"pubmed":["35686618"],"doi":["10.1002/chem.202201359"]}}