biostudies-literatureGraedel NNRoyal Academy of EngineeringWellcome TrustEngineering and Physical Sciences Research Council2058-2073https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546489biostudies-literatureUnknown88(5)<h4>Purpose</h4>We investigate the use of TURBINE, a 3D radial-Cartesian acquisition scheme in which EPI planes are rotated about the phase-encoding axis to acquire a cylindrical k-space for high-fidelity ultrahigh isotropic resolution fMRI at 7 Tesla with minimal distortion and blurring.<h4>Methods</h4>An improved, completely self-navigated version of the TURBINE sampling scheme was designed for fMRI at 7 Telsa. To demonstrate the image quality and spatial specificity of the acquisition, thin-slab visual and motor BOLD fMRI at 0.67 mm isotropic resolution (16 mm slab, TRvol = 2.32 s), and 0.8 × 0.8 × 2.0 mm (whole-brain, TRvol = 2.4 s) data were acquired. To prioritize the high spatial fidelity, we employed a temporally regularized reconstruction to improve sensitivity without any spatial bias.<h4>Results</h4>TURBINE images provide high structural fidelity with almost no distortion, dropout, or T₂ * blurring for the thin-slab acquisitions compared to conventional 3D EPI owing to the radial sampling in-plane and the short echo train used. This results in activation that can be localized to pre- and postcentral gyri in a motor task, for example, with excellent correspondence to brain structure measured by a T₁ -MPRAGE. The benefits of TURBINE (low distortion, dropout, blurring) are reduced for the whole-brain acquisition due to the longer EPI train. We demonstrate robust BOLD activation at 0.67 mm isotropic resolution (thin-slab) and also anisotropic 0.8 × 0.8 × 2.0 mm (whole-brain) acquisitions.<h4>Conclusion</h4>TURBINE is a promising acquisition approach for high-resolution, minimally distorted fMRI at 7 Tesla and could be particularly useful for fMRI in areas of high B₀ inhomogeneity.Magnetic resonance in medicineUltrahigh Resolution fMRI at 7T Using Radial-Cartesian TURBINE Sampling.PMC9546489RF201617∖16∖23203139/Z/16/ZEP/T013133/1203147/Z/16/Z202788/Z/16/ZGraedel NNChiew MMiller KLfalseUltrahigh Resolution fMRI at 7T Using Radial-Cartesian TURBINE Sampling.<h4>Purpose</h4>We investigate the use of TURBINE, a 3D radial-Cartesian acquisition scheme in which EPI planes are rotated about the phase-encoding axis to acquire a cylindrical k-space for high-fidelity ultrahigh isotropic resolution fMRI at 7 Tesla with minimal distortion and blurring.<h4>Methods</h4>An improved, completely self-navigated version of the TURBINE sampling scheme was designed for fMRI at 7 Telsa. To demonstrate the image quality and spatial specificity of the acquisition, thin-slab visual and motor BOLD fMRI at 0.67 mm isotropic resolution (16 mm slab, TRvol = 2.32 s), and 0.8 × 0.8 × 2.0 mm (whole-brain, TRvol = 2.4 s) data were acquired. To prioritize the high spatial fidelity, we employed a temporally regularized reconstruction to improve sensitivity without any spatial bias.<h4>Results</h4>TURBINE images provide high structural fidelity with almost no distortion, dropout, or T₂ * blurring for the thin-slab acquisitions compared to conventional 3D EPI owing to the radial sampling in-plane and the short echo train used. This results in activation that can be localized to pre- and postcentral gyri in a motor task, for example, with excellent correspondence to brain structure measured by a T₁ -MPRAGE. The benefits of TURBINE (low distortion, dropout, blurring) are reduced for the whole-brain acquisition due to the longer EPI train. We demonstrate robust BOLD activation at 0.67 mm isotropic resolution (thin-slab) and also anisotropic 0.8 × 0.8 × 2.0 mm (whole-brain) acquisitions.<h4>Conclusion</h4>TURBINE is a promising acquisition approach for high-resolution, minimally distorted fMRI at 7 Tesla and could be particularly useful for fMRI in areas of high B₀ inhomogeneity.2022-01-01T00:00:00Z2022 Nov2025-04-04T20:04:11.345Z2025-04-04T20:04:11.345ZS-EPMC95464893578542910.1002/mrm.29359