{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nies VJM"],"funding":["HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","European Foundation for the Study of Diabetes","March of Dimes Foundation","Jan Kornelis de Cock Stichting","Larry L. Hillblom Foundation","NCI NIH HHS"],"pagination":["e2122382119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546606"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(40)"],"pubmed_abstract":["Fibroblast growth factor 1 (FGF1) is an autocrine growth factor released from adipose tissue during over-nutrition or fasting to feeding transition. While local actions underlie the majority of FGF1's anti-diabetic functions, the molecular mechanisms downstream of adipose FGF receptor signaling are unclear. We investigated the effects of FGF1 on glucose uptake and its underlying mechanism in murine 3T3-L1 adipocytes and in ex vivo adipose explants from mice. FGF1 increased glucose uptake in 3T3-L1 adipocytes and epididymal WAT (eWAT) and inguinal WAT (iWAT). Conversely, glucose uptake was reduced in eWAT and iWAT of FGF1 knockout mice. We show that FGF1 acutely increased adipocyte glucose uptake via activation of the insulin-sensitive glucose transporter GLUT4, involving dynamic crosstalk "],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Autocrine FGF1 signaling promotes glucose uptake in adipocytes."],"pmcid":["PMC9546606"],"funding_grant_id":["R01DK057978","Endowed Chair","Johan W. Jonker","P30 CA014195","R01 DK057978","2021-D-001-NET","JW Jonker"],"pubmed_authors":["Struik D","Nies VJM","Kruit JK","Verkade HJ","Liu S","van Zutphen T","Jonker JW","Liu W","Downes M","Evans RM"],"additional_accession":[]},"is_claimable":false,"name":"Autocrine FGF1 signaling promotes glucose uptake in adipocytes.","description":"Fibroblast growth factor 1 (FGF1) is an autocrine growth factor released from adipose tissue during over-nutrition or fasting to feeding transition. While local actions underlie the majority of FGF1's anti-diabetic functions, the molecular mechanisms downstream of adipose FGF receptor signaling are unclear. We investigated the effects of FGF1 on glucose uptake and its underlying mechanism in murine 3T3-L1 adipocytes and in ex vivo adipose explants from mice. FGF1 increased glucose uptake in 3T3-L1 adipocytes and epididymal WAT (eWAT) and inguinal WAT (iWAT). Conversely, glucose uptake was reduced in eWAT and iWAT of FGF1 knockout mice. We show that FGF1 acutely increased adipocyte glucose uptake via activation of the insulin-sensitive glucose transporter GLUT4, involving dynamic crosstalk ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-05T11:20:36.179Z","creation":"2025-04-05T11:20:36.179Z"},"accession":"S-EPMC9546606","cross_references":{"pubmed":["36161959"],"doi":["10.1073/pnas.2122382119"]}}