{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Ye X"],"pubmed_abstract":["<h4>Background</h4>Gasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis. However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) remains poorly understood.<h4>Methods</h4>Serum levels of GSDMD and IL-18 in ST-segment elevation myocardial infarction (STEMI) patients were measured by ELISA. The expression of GSDMD and GSDMD N-terminal (GSDMD-NT) <i>in vivo</i> and <i>in vitro</i> was assessed by western blot and immunofluorescence staining. GSDMD<sup>-/-</sup> mice and wild type (WT) mice were induced MI/RI, followed by cardiac ultrasound and histological analysis.<h4>Results</h4>Clinically, patients suffering from STEMI after percutaneous coronary intervention (PCI) exhibited higher levels of GSDMD and IL-18 than that in the controls. <i>In"],"journal":["Frontiers in immunology"],"pagination":["893914"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9546776"],"repository":["biostudies-literature"],"pubmed_title":["GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis."],"pmcid":["PMC9546776"],"pubmed_authors":["Wu Z","Zhang Y","Hu W","Xu C","Ju D","Ye X","Luan J","Zhang P"],"additional_accession":[]},"is_claimable":false,"name":"GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis.","description":"<h4>Background</h4>Gasdermin D (GSDMD) plays an essential role in the pathway of pyroptosis. However, whether GSDMD participates in myocardial ischaemia/reperfusion injury (MI/RI) remains poorly understood.<h4>Methods</h4>Serum levels of GSDMD and IL-18 in ST-segment elevation myocardial infarction (STEMI) patients were measured by ELISA. The expression of GSDMD and GSDMD N-terminal (GSDMD-NT) <i>in vivo</i> and <i>in vitro</i> was assessed by western blot and immunofluorescence staining. GSDMD<sup>-/-</sup> mice and wild type (WT) mice were induced MI/RI, followed by cardiac ultrasound and histological analysis.<h4>Results</h4>Clinically, patients suffering from STEMI after percutaneous coronary intervention (PCI) exhibited higher levels of GSDMD and IL-18 than that in the controls. <i>In","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T16:06:56.073Z","creation":"2025-02-19T01:28:03.415Z"},"accession":"S-EPMC9546776","cross_references":{"pubmed":["36217543"],"doi":["10.3389/fimmu.2022.893914"]}}