{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Zhang S"],"pubmed_abstract":["Human endometrium undergoes cycles of regeneration in women of reproductive age. The endometrial mesenchymal stromal/stem cells (eMSC) contribute to this process. Notch signaling is essential for homeostasis of somatic stem cells. However, its role in eMSC remains unclear. We show with gain- and loss-of-function experiments that activation of Notch signaling promotes eMSC maintenance, while inhibition induces opposite effect. The activation of Notch signaling better maintains eMSC in a quiescent state. However, these quiescent eMSC can re-enter the cell cycle depending on the Notch and Wnt activities in the microenvironment, suggesting a crosstalk between the two signaling pathways. We further show that the Notch signaling is involved in endometrial remodeling event in a mouse menstrual-li"],"journal":["Communications biology"],"pagination":["1064"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9547015"],"repository":["biostudies-literature"],"pubmed_title":["The role of Notch signaling in endometrial mesenchymal stromal/stem-like cells maintenance."],"pmcid":["PMC9547015"],"pubmed_authors":["Yeung WSB","Chan RWS","Ng EHY","Zhang S"],"additional_accession":[]},"is_claimable":false,"name":"The role of Notch signaling in endometrial mesenchymal stromal/stem-like cells maintenance.","description":"Human endometrium undergoes cycles of regeneration in women of reproductive age. The endometrial mesenchymal stromal/stem cells (eMSC) contribute to this process. Notch signaling is essential for homeostasis of somatic stem cells. However, its role in eMSC remains unclear. We show with gain- and loss-of-function experiments that activation of Notch signaling promotes eMSC maintenance, while inhibition induces opposite effect. The activation of Notch signaling better maintains eMSC in a quiescent state. However, these quiescent eMSC can re-enter the cell cycle depending on the Notch and Wnt activities in the microenvironment, suggesting a crosstalk between the two signaling pathways. We further show that the Notch signaling is involved in endometrial remodeling event in a mouse menstrual-li","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-25T17:36:35.686Z","creation":"2025-04-06T05:23:09.276Z"},"accession":"S-EPMC9547015","cross_references":{"pubmed":["36207605"],"doi":["10.1038/s42003-022-04044-x"]}}