biostudies-literatureSharifi HNational Center for Advancing Translational SciencesNational Center of Research ResourcesNCATS NIH HHSNCRR NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood Institute857-863https://www.ebi.ac.uk/biostudies/studies/S-EPMC9547031biostudies-literatureUnknown13(6)<h4>Purpose</h4>Mouse models are widely utilized to enhance our understanding of cardiac disease. The goal of this study is to investigate the reproducibility of strain parameters that were measured in mice using cardiac magnetic resonance (CMR) feature-tracking (CMR42, Canada).<h4>Methods</h4>We retrospectively analyzed black-blood CMR datasets from thirteen C57BL/6 B6.SJL-CD45.1 mice (N = 10 female, N = 3 male) that were imaged previously. The circumferential, longitudinal, and radial (E_cc, E_ll, and E_rr, respectively) parameters of strain were measured in the mid-ventricular region of the left ventricle. Intraobserver and interobserver reproducibility were assessed for both the end-systolic (ES) and peak strain.<h4>Results</h4>The ES strain had larger intCardiovascular engineering and technologyReproducibility of Systolic Strain in Mice Using Cardiac Magnetic Resonance Feature Tracking of Black-Blood Cine Images.PMC9547031U01HL133359S10RR029541UL1TR001998R01 HL146676U01 HL133359UL1 TR001998S10 RR029541R01 HL163977Campbell KSMann CKLiu ZQFerguson CRRockward ALNoor AZWenk JFSharifi HMoonschi FLeung SWNikou AfalseReproducibility of Systolic Strain in Mice Using Cardiac Magnetic Resonance Feature Tracking of Black-Blood Cine Images.<h4>Purpose</h4>Mouse models are widely utilized to enhance our understanding of cardiac disease. The goal of this study is to investigate the reproducibility of strain parameters that were measured in mice using cardiac magnetic resonance (CMR) feature-tracking (CMR42, Canada).<h4>Methods</h4>We retrospectively analyzed black-blood CMR datasets from thirteen C57BL/6 B6.SJL-CD45.1 mice (N = 10 female, N = 3 male) that were imaged previously. The circumferential, longitudinal, and radial (E_cc, E_ll, and E_rr, respectively) parameters of strain were measured in the mid-ventricular region of the left ventricle. Intraobserver and interobserver reproducibility were assessed for both the end-systolic (ES) and peak strain.<h4>Results</h4>The ES strain had larger int2022-01-01T00:00:00Z2022 Dec2025-04-22T13:18:09.819Z2025-04-06T00:34:00.563ZS-EPMC95470313539669210.1007/s13239-022-00621-7