biostudies-literatureUnknown26Fitton RThis scoping review assessed the effect of anti-inflammatory medications in mental disorders. A search in Medline and the Cochrane database focusing on randomised controlled trials and systematic reviews identified 53 primary research articles, conducted in major depression, bipolar disorder, schizophrenia and somatic symptom disorders and related disorders (SSRD). The findings suggest that there is scope to consider the use of anti-inflammatory agents in mental disorders, however, not as a one-size-fits-all solution. Treatment could be especially helpful in subgroups with evidence of baseline inflammation. Anti-inflammatory medications that seem mostly effective in bipolar disorder or major depressive disorder, such as Celecoxib, Pioglitazone and statins, may differ from the ones with indBrain, behavior, & immunity - health100518https://www.ebi.ac.uk/biostudies/studies/S-EPMC9547233biostudies-literatureAnti-inflammatory medications for the treatment of mental disorders: A scoping review.PMC9547233Heseltine-Carp WFitton Rvan der Feltz-Cornelis CSweetman JfalseAnti-inflammatory medications for the treatment of mental disorders: A scoping review.This scoping review assessed the effect of anti-inflammatory medications in mental disorders. A search in Medline and the Cochrane database focusing on randomised controlled trials and systematic reviews identified 53 primary research articles, conducted in major depression, bipolar disorder, schizophrenia and somatic symptom disorders and related disorders (SSRD). The findings suggest that there is scope to consider the use of anti-inflammatory agents in mental disorders, however, not as a one-size-fits-all solution. Treatment could be especially helpful in subgroups with evidence of baseline inflammation. Anti-inflammatory medications that seem mostly effective in bipolar disorder or major depressive disorder, such as Celecoxib, Pioglitazone and statins, may differ from the ones with ind2022-01-01T00:00:00Z2022 Dec2025-04-29T10:59:32.863Z2025-04-06T19:49:01.605ZS-EPMC95472333621737410.1016/j.bbih.2022.100518