{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(1)"],"submitter":["Park HM"],"pubmed_abstract":["RNA-protein interactions are crucial for diverse biological processes. In prokaryotes, RNA-protein interactions enable adaptive immunity through CRISPR-Cas systems. These defence systems utilize CRISPR RNA (crRNA) templates acquired from past infections to destroy foreign genetic elements through crRNA-mediated nuclease activities of Cas proteins. Thanks to the programmability and specificity of CRISPR-Cas systems, CRISPR-based antimicrobials have the potential to be repurposed as new types of antibiotics. Unlike traditional antibiotics, these CRISPR-based antimicrobials can be designed to target specific bacteria and minimize detrimental effects on the human microbiome during antibacterial therapy. In this study, we explore the potential of CRISPR-based antimicrobials by optimizing the RN"],"journal":["Biology direct"],"pagination":["27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9547417"],"repository":["biostudies-literature"],"pubmed_title":["In silico optimization of RNA-protein interactions for CRISPR-Cas13-based antimicrobials."],"pmcid":["PMC9547417"],"pubmed_authors":["De Neve W","Park Y","Vankerschaver J","Berani U","Bang E","Park HM","Shim H","Van Messem A"],"additional_accession":[]},"is_claimable":false,"name":"In silico optimization of RNA-protein interactions for CRISPR-Cas13-based antimicrobials.","description":"RNA-protein interactions are crucial for diverse biological processes. In prokaryotes, RNA-protein interactions enable adaptive immunity through CRISPR-Cas systems. These defence systems utilize CRISPR RNA (crRNA) templates acquired from past infections to destroy foreign genetic elements through crRNA-mediated nuclease activities of Cas proteins. Thanks to the programmability and specificity of CRISPR-Cas systems, CRISPR-based antimicrobials have the potential to be repurposed as new types of antibiotics. Unlike traditional antibiotics, these CRISPR-based antimicrobials can be designed to target specific bacteria and minimize detrimental effects on the human microbiome during antibacterial therapy. In this study, we explore the potential of CRISPR-based antimicrobials by optimizing the RN","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-31T16:05:19.863Z","creation":"2025-02-19T01:27:44.552Z"},"accession":"S-EPMC9547417","cross_references":{"pubmed":["36207756"],"doi":["10.1186/s13062-022-00339-5"]}}