{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(9)"],"submitter":["Wei X"],"pubmed_abstract":["Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is a marker of poor prognosis. However, the reliable biomarkers of post-LT HCC recurrence remain to be identified. In this study, serial peripheral blood samples from the LT recipients with and without HCC recurrence were collected at five time points. Single-cell mass cytomertry (CyTOF) was utilized for the in-depth analysis of peripheral blood monocellular cells (PBMCs). CyTOF analysis showed that at 3 weeks post-LT, the activated immune cell population was increased, while the fraction of immune cells with suppressive functions (myeloid-derived suppressive cells) was reduced. The post-LT immune composition in patients with LT for HCC was enormously different from that in patients with LT for causes other than "],"journal":["American journal of cancer research"],"pagination":["4160-4176"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9548010"],"repository":["biostudies-literature"],"pubmed_title":["Prediction of tumor recurrence by distinct immunoprofiles in liver transplant patients based on mass cytometry."],"pmcid":["PMC9548010"],"pubmed_authors":["Xie W","Yin W","Li C","Yang M","Zheng S","Lu D","Wei X","Pan B","Zeng X","Wang K","Yang F","Cen B","Fan G","Khan AR","Su R","Shu W","Xie H","Chen W","Pan L","Zhuang L","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"Prediction of tumor recurrence by distinct immunoprofiles in liver transplant patients based on mass cytometry.","description":"Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is a marker of poor prognosis. However, the reliable biomarkers of post-LT HCC recurrence remain to be identified. In this study, serial peripheral blood samples from the LT recipients with and without HCC recurrence were collected at five time points. Single-cell mass cytomertry (CyTOF) was utilized for the in-depth analysis of peripheral blood monocellular cells (PBMCs). CyTOF analysis showed that at 3 weeks post-LT, the activated immune cell population was increased, while the fraction of immune cells with suppressive functions (myeloid-derived suppressive cells) was reduced. The post-LT immune composition in patients with LT for HCC was enormously different from that in patients with LT for causes other than ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T12:18:51.184Z","creation":"2025-04-05T12:18:51.184Z"},"accession":"S-EPMC9548010","cross_references":{"pubmed":["36225628"]}}