{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang H"],"funding":["National Natural Science Foundation of China"],"pagination":["169"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9548188"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and distinct consequences in osteosarcoma tumorigenicity. However, the potential of CD151 as a therapeutic target has not yet been sufficiently explored. Here, we performed integrated transcriptomic and metabolomic analyses of osteosarcoma and identified sphingolipid metabolism as the top CD151-regulated pathway. CD151 regulates sphingolipid metabolism primarily through SPTCL1, the first rate-limiting enzyme in sphingolipid biosynthesis. Mechanistically, depletion of CD151 enhanced c-myc polyubiquitination and subsequent degradation. c-myc is vital for the transcriptional activation of SPTLC"],"journal":["Cell & bioscience"],"pubmed_title":["Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity."],"pmcid":["PMC9548188"],"funding_grant_id":["81902734","82072969","81772859"],"pubmed_authors":["Hua Y","Jin X","Shen J","Wang C","Ma X","Wang H","Sun W","Xu J","Sun M","Zhang T","Zhang Y","Zan P","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity.","description":"Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and distinct consequences in osteosarcoma tumorigenicity. However, the potential of CD151 as a therapeutic target has not yet been sufficiently explored. Here, we performed integrated transcriptomic and metabolomic analyses of osteosarcoma and identified sphingolipid metabolism as the top CD151-regulated pathway. CD151 regulates sphingolipid metabolism primarily through SPTCL1, the first rate-limiting enzyme in sphingolipid biosynthesis. Mechanistically, depletion of CD151 enhanced c-myc polyubiquitination and subsequent degradation. c-myc is vital for the transcriptional activation of SPTLC","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-06-01T02:11:08.522Z","creation":"2025-02-19T01:28:38.555Z"},"accession":"S-EPMC9548188","cross_references":{"pubmed":["36209197"],"doi":["10.1186/s13578-022-00900-9"]}}