{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(10)"],"submitter":["Lin TC"],"pubmed_abstract":["Septic shock can aggravate organ dysfunction and even lead to death. <i>Juniperus communis</i> (JCo) extract has been experimentally demonstrated to have anti-inflammatory and antioxidant effects. We investigated the anti-inflammatory and antioxidant mechanism of JCo extract in vivo and in vitro. In a lipopolysaccharide (LPS)-induced acute kidney injury rat model, JCo extract improved animal survival, reduced kidney injury scores, suppressed kidney injury molecule-1, and preserved E-cadherin expression from LPS damage, as demonstrated by the immunohistochemistry examinations of the rat kidneys. In LPS-stimulated NRK-52E cells, JCo extract inhibited nuclear factor-κB (NF-κB) and increased adenosine monophosphate-activated protein kinase (AMPK) expression, prompting the activation of the ant"],"journal":["Food science & nutrition"],"pagination":["3405-3414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9548363"],"repository":["biostudies-literature"],"pubmed_title":["<i>Juniperus communis</i> extract ameliorates lipopolysaccharide-induced acute kidney injury through the adenosine monophosphate-activated protein kinase pathway."],"pmcid":["PMC9548363"],"pubmed_authors":["Lin TC","Lee CJ","Chang KF","Lu CW"],"additional_accession":[]},"is_claimable":false,"name":"<i>Juniperus communis</i> extract ameliorates lipopolysaccharide-induced acute kidney injury through the adenosine monophosphate-activated protein kinase pathway.","description":"Septic shock can aggravate organ dysfunction and even lead to death. <i>Juniperus communis</i> (JCo) extract has been experimentally demonstrated to have anti-inflammatory and antioxidant effects. We investigated the anti-inflammatory and antioxidant mechanism of JCo extract in vivo and in vitro. In a lipopolysaccharide (LPS)-induced acute kidney injury rat model, JCo extract improved animal survival, reduced kidney injury scores, suppressed kidney injury molecule-1, and preserved E-cadherin expression from LPS damage, as demonstrated by the immunohistochemistry examinations of the rat kidneys. In LPS-stimulated NRK-52E cells, JCo extract inhibited nuclear factor-κB (NF-κB) and increased adenosine monophosphate-activated protein kinase (AMPK) expression, prompting the activation of the ant","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T23:03:06.512Z","creation":"2025-02-19T01:01:52.788Z"},"accession":"S-EPMC9548363","cross_references":{"pubmed":["36249972"],"doi":["10.1002/fsn3.2941"]}}