biostudies-literatureUnknown10(10)Lin TCSeptic shock can aggravate organ dysfunction and even lead to death. <i>Juniperus communis</i> (JCo) extract has been experimentally demonstrated to have anti-inflammatory and antioxidant effects. We investigated the anti-inflammatory and antioxidant mechanism of JCo extract in vivo and in vitro. In a lipopolysaccharide (LPS)-induced acute kidney injury rat model, JCo extract improved animal survival, reduced kidney injury scores, suppressed kidney injury molecule-1, and preserved E-cadherin expression from LPS damage, as demonstrated by the immunohistochemistry examinations of the rat kidneys. In LPS-stimulated NRK-52E cells, JCo extract inhibited nuclear factor-κB (NF-κB) and increased adenosine monophosphate-activated protein kinase (AMPK) expression, prompting the activation of the antFood science & nutrition3405-3414https://www.ebi.ac.uk/biostudies/studies/S-EPMC9548363biostudies-literature<i>Juniperus communis</i> extract ameliorates lipopolysaccharide-induced acute kidney injury through the adenosine monophosphate-activated protein kinase pathway.PMC9548363Lin TCLee CJChang KFLu CWfalse<i>Juniperus communis</i> extract ameliorates lipopolysaccharide-induced acute kidney injury through the adenosine monophosphate-activated protein kinase pathway.Septic shock can aggravate organ dysfunction and even lead to death. <i>Juniperus communis</i> (JCo) extract has been experimentally demonstrated to have anti-inflammatory and antioxidant effects. We investigated the anti-inflammatory and antioxidant mechanism of JCo extract in vivo and in vitro. In a lipopolysaccharide (LPS)-induced acute kidney injury rat model, JCo extract improved animal survival, reduced kidney injury scores, suppressed kidney injury molecule-1, and preserved E-cadherin expression from LPS damage, as demonstrated by the immunohistochemistry examinations of the rat kidneys. In LPS-stimulated NRK-52E cells, JCo extract inhibited nuclear factor-κB (NF-κB) and increased adenosine monophosphate-activated protein kinase (AMPK) expression, prompting the activation of the ant2022-01-01T00:00:00Z2022 Oct2025-04-04T23:03:06.512Z2025-02-19T01:01:52.788ZS-EPMC95483633624997210.1002/fsn3.2941