{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Kwon HR"],"pubmed_abstract":["<h4>Purpose</h4>We evaluated baseline <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters for predicting prognosis in patients with head and neck squamous cell carcinoma (HNSCC) who were receiving immune checkpoint inhibitors (ICIs). In addition, we also investigated the relationships between immunohistochemical (IHC) biomarkers and metabolic parameters.<h4>Materials and methods</h4>A total of 39 patients with HNSCC who underwent <sup>18</sup>F-FDG PET/CT prior to ICI therapy between November 2015 and December 2020 were enrolled. PET parameters of tumor lesions included standardized uptake values, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and spleen-to-liver ratio (SLR). Clinical variables, IHC markers, a"],"journal":["Frontiers in medicine"],"pagination":["896494"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9548588"],"repository":["biostudies-literature"],"pubmed_title":["Metabolic parameters on baseline <sup>18</sup>F-FDG PET/CT are potential predictive biomarkers for immunotherapy in patients with head and neck squamous cell carcinoma."],"pmcid":["PMC9548588"],"pubmed_authors":["Ahn MJ","Jung HA","Cho J","Choi JY","Lee SH","Moon SH","Kwon HR","Park S","Lee KH"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic parameters on baseline <sup>18</sup>F-FDG PET/CT are potential predictive biomarkers for immunotherapy in patients with head and neck squamous cell carcinoma.","description":"<h4>Purpose</h4>We evaluated baseline <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) metabolic parameters for predicting prognosis in patients with head and neck squamous cell carcinoma (HNSCC) who were receiving immune checkpoint inhibitors (ICIs). In addition, we also investigated the relationships between immunohistochemical (IHC) biomarkers and metabolic parameters.<h4>Materials and methods</h4>A total of 39 patients with HNSCC who underwent <sup>18</sup>F-FDG PET/CT prior to ICI therapy between November 2015 and December 2020 were enrolled. PET parameters of tumor lesions included standardized uptake values, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and spleen-to-liver ratio (SLR). Clinical variables, IHC markers, a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:23:25.626Z","creation":"2025-04-04T19:23:25.626Z"},"accession":"S-EPMC9548588","cross_references":{"pubmed":["36226146"],"doi":["10.3389/fmed.2022.896494"]}}