biostudies-literatureSchokman AAustralian GovernmentAustralian Research Councilzsac156https://www.ebi.ac.uk/biostudies/studies/S-EPMC9548672biostudies-literatureUnknown45(10)<h4>Study objectives</h4>To systematically determine subjective and objective outcome measures used to measure the efficacy of narcolepsy interventions in randomized controlled trials (RCTs) in adults and children and assess psychometric properties of patient-reported outcome measures (PROMs) used.<h4>Methods</h4>We searched bibliographical databases and clinical trial registries for narcolepsy RCTs and extracted objective and subjective outcome measures. If PROMs were used, we searched for psychometric studies conducted in a narcolepsy population using bibliographical databases and appraised using Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines.<h4>Results</h4>In total, 80 different outcome measures were used across 100 RCTs. Epworth SleepSleepEvaluation of psychometric properties of patient-reported outcome measures frequently used in narcolepsy randomized controlled trials: a systematic review.PMC9548672ID CE200100025Cheung JMYGlozier NBin YSKairaitis KNaehrig DSchokman AfalseEvaluation of psychometric properties of patient-reported outcome measures frequently used in narcolepsy randomized controlled trials: a systematic review.<h4>Study objectives</h4>To systematically determine subjective and objective outcome measures used to measure the efficacy of narcolepsy interventions in randomized controlled trials (RCTs) in adults and children and assess psychometric properties of patient-reported outcome measures (PROMs) used.<h4>Methods</h4>We searched bibliographical databases and clinical trial registries for narcolepsy RCTs and extracted objective and subjective outcome measures. If PROMs were used, we searched for psychometric studies conducted in a narcolepsy population using bibliographical databases and appraised using Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines.<h4>Results</h4>In total, 80 different outcome measures were used across 100 RCTs. Epworth Sleep2022-01-01T00:00:00Z2022 Oct2026-04-12T19:27:36.072Z2025-04-05T11:37:59.886ZS-EPMC95486723579758910.1093/sleep/zsac156