biostudies-literatureChang XFundamental Research Funds for the Central UniversitiesNCRR NIH HHSNIGMS NIH HHS993866https://www.ebi.ac.uk/biostudies/studies/S-EPMC9549145biostudies-literatureUnknown13"<i>Cognitive dysmetria" theory of</i> schizophrenia (SZ) has highlighted that the cerebellum plays a critical role in understanding the pathogenesis and cognitive impairment in SZ. Despite some studies have reported the structural disruption of the cerebellum in SZ using whole brain approach, specific focus on the <i>voxel</i>-<i>w</i>ise <i>changes of cerebellar WM microstructure and its associations with cognition impairments in SZ were less investigated.</i> To <i>further explore the voxel</i>-<i>w</i>ise <i>structural disruption of the cerebellum in SZ, the present study comprehensively examined</i> volume and diffusion features of cerebellar white matter in SZ at the voxel level (42 SZ vs. 52 controls) and correlated the observed alterations with the cognitive impairments measured byFrontiers in psychiatryAlterations of cerebellar white matter integrity and associations with cognitive impairments in schizophrenia.PMC9549145P20 RR021938No. SWU2209505P20 GM103472Dong DJia XWang YChang XfalseAlterations of cerebellar white matter integrity and associations with cognitive impairments in schizophrenia."<i>Cognitive dysmetria" theory of</i> schizophrenia (SZ) has highlighted that the cerebellum plays a critical role in understanding the pathogenesis and cognitive impairment in SZ. Despite some studies have reported the structural disruption of the cerebellum in SZ using whole brain approach, specific focus on the <i>voxel</i>-<i>w</i>ise <i>changes of cerebellar WM microstructure and its associations with cognition impairments in SZ were less investigated.</i> To <i>further explore the voxel</i>-<i>w</i>ise <i>structural disruption of the cerebellum in SZ, the present study comprehensively examined</i> volume and diffusion features of cerebellar white matter in SZ at the voxel level (42 SZ vs. 52 controls) and correlated the observed alterations with the cognitive impairments measured by2022-01-01T00:00:00Z20222025-09-01T03:07:28.135Z2025-04-04T19:23:20.051ZS-EPMC95491453622610610.3389/fpsyt.2022.993866