biostudies-literatureUnknown13Monti PMinistero Della SaluteCompagnia di San PaoloThe <i>TP53</i> tumor suppressor gene is one of the most studied gene in virtue of its ability to prevent cancer development by regulating apoptosis, cell cycle arrest, DNA repair, autophagy and senescence. Furthermore, the modulation of metabolism by P53 is fundamental for tumor suppressor activity. Studies in mouse models showed that mice carrying <i>TP53</i> mutations affecting the acetylation in the DNA binding domain still retain the ability to transactivate genes involved in metabolism. Noteworthy, mice expressing the triple 3KR or the single K117R mutant do not show early on-set tumor development in contrast to <i>TP53</i> ^<i>-/-</i> mice. Interestingly, the mouse K117R mutation corresponds to the human tumor-derived K120R modification, which abrogates P53-dependent activFrontiers in genetics974662https://www.ebi.ac.uk/biostudies/studies/S-EPMC9549157biostudies-literatureMutant p53^K120R expression enables a partial capacity to modulate metabolism.PMC9549157Fronza GDegan PFoggetti GSpeciale AVelkova IRavera SMenichini PMonti PfalseMutant p53^K120R expression enables a partial capacity to modulate metabolism.The <i>TP53</i> tumor suppressor gene is one of the most studied gene in virtue of its ability to prevent cancer development by regulating apoptosis, cell cycle arrest, DNA repair, autophagy and senescence. Furthermore, the modulation of metabolism by P53 is fundamental for tumor suppressor activity. Studies in mouse models showed that mice carrying <i>TP53</i> mutations affecting the acetylation in the DNA binding domain still retain the ability to transactivate genes involved in metabolism. Noteworthy, mice expressing the triple 3KR or the single K117R mutant do not show early on-set tumor development in contrast to <i>TP53</i> ^<i>-/-</i> mice. Interestingly, the mouse K117R mutation corresponds to the human tumor-derived K120R modification, which abrogates P53-dependent activ2022-01-01T00:00:00Z20222025-04-25T20:48:34.805Z2025-04-06T08:33:33.451ZS-EPMC95491573622618110.3389/fgene.2022.974662