{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Al-Ahmadi W"],"funding":["Austrian Science Fund FWF","British Heart Foundation","Saudi Arabia Cultural Bureau in London"],"pagination":["e21892"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9549671"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(10)"],"pubmed_abstract":["Atherosclerosis is a chronic inflammatory disorder of the vasculature regulated by cytokines. We have previously shown that extracellular signal-regulated kinase-1/2 (ERK1/2) plays an important role in serine 727 phosphorylation of signal transducer and activator of transcription-1 (STAT1) transactivation domain, which is required for maximal interferon-γ signaling, and the regulation of modified LDL uptake by macrophages in vitro. Unfortunately, the roles of ERK1/2 and STAT1 serine 727 phosphorylation in atherosclerosis are poorly understood and were investigated using ERK1 deficient mice (ERK2 knockout mice die in utero) and STAT1 knock-in mice (serine 727 replaced by alanine; STAT1 S727A). Mouse Atherosclerosis RT² Profiler PCR Array analysis showed that ERK1 deficiency and STAT1 S727A "],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation."],"pmcid":["PMC9549671"],"funding_grant_id":["PG/12/50/29691","PG/16/25/32097","FS/17/75/33257","W 1261"],"pubmed_authors":["Webberley TS","Decker T","Hughes TR","Al-Ahmadi W","Harris F","Alotibi R","Alahmadi A","Williams JO","Joseph A","Ramji DP","Chan YH"],"additional_accession":[]},"is_claimable":false,"name":"Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation.","description":"Atherosclerosis is a chronic inflammatory disorder of the vasculature regulated by cytokines. We have previously shown that extracellular signal-regulated kinase-1/2 (ERK1/2) plays an important role in serine 727 phosphorylation of signal transducer and activator of transcription-1 (STAT1) transactivation domain, which is required for maximal interferon-γ signaling, and the regulation of modified LDL uptake by macrophages in vitro. Unfortunately, the roles of ERK1/2 and STAT1 serine 727 phosphorylation in atherosclerosis are poorly understood and were investigated using ERK1 deficient mice (ERK2 knockout mice die in utero) and STAT1 knock-in mice (serine 727 replaced by alanine; STAT1 S727A). Mouse Atherosclerosis RT² Profiler PCR Array analysis showed that ERK1 deficiency and STAT1 S727A ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-06-03T10:28:02.724Z","creation":"2025-04-04T09:29:39.106Z"},"accession":"S-EPMC9549671","cross_references":{"pubmed":["34569651"],"doi":["10.1096/fj.202100571RR"]}}