biostudies-literatureUnknown12(10)Kurano MMitsubishi FoundationJapan Agency for Medical Research and Development<h4>Background</h4>A heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID-19). Therefore, investigating biomarkers associated with disease severity is important for understanding the mechanisms responsible for this heterogeneity and for developing novel agents to prevent critical conditions. This study aimed to elucidate the modulations of sphingolipids and glycerophospholipids, which have been shown to possess potent biological properties.<h4>Methods</h4>We measured the serum sphingolipid and glycerophospholipid levels in a total of 887 samples from 215 COVID-19 subjects, plus 115 control subjects without infectious diseases and 109 subjects with infectious diseases other than COVID-19.<h4>Results</h4>We observed the dynamic modulations of sphingolipids Clinical and translational medicinee1069https://www.ebi.ac.uk/biostudies/studies/S-EPMC9549873biostudies-literatureDynamic modulations of sphingolipids and glycerophospholipids in COVID-19.PMC9549873Jubishi DSaigusa DKurano MKano KOkamoto KHarada SAoki JSakai EOkugawa SMoriya KDoi KYatomi YHashimoto HfalseDynamic modulations of sphingolipids and glycerophospholipids in COVID-19.<h4>Background</h4>A heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID-19). Therefore, investigating biomarkers associated with disease severity is important for understanding the mechanisms responsible for this heterogeneity and for developing novel agents to prevent critical conditions. This study aimed to elucidate the modulations of sphingolipids and glycerophospholipids, which have been shown to possess potent biological properties.<h4>Methods</h4>We measured the serum sphingolipid and glycerophospholipid levels in a total of 887 samples from 215 COVID-19 subjects, plus 115 control subjects without infectious diseases and 109 subjects with infectious diseases other than COVID-19.<h4>Results</h4>We observed the dynamic modulations of sphingolipids 2022-01-01T00:00:00Z2022 Oct2025-04-22T12:07:01.881Z2025-02-19T02:33:05.42ZS-EPMC95498733621475410.1002/ctm2.1069